Description

(4S)-4,9-Bis(Acetyloxy)-10-[(Acetyloxy)Methyl]-4-Ethyl-1H-Pyrano[3',4':6,7]Indolizino[1,2-B]Quinoline-3,14(4H,12H)-Dione is a complex, high-purity alkaloid-derived intermediate of significant interest in advanced pharmaceutical research and development. This compound matters for its role as a key synthetic precursor in the production of novel therapeutic agents, particularly in oncology and anti-infective drug discovery. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in cutting-edge medicinal chemistry programs.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the multi-step synthesis of complex drug candidates, particularly those with indolizinoquinoline scaffolds.
• Oncology Research: Used in the development and study of novel topoisomerase inhibitors and other anti-cancer agents targeting DNA replication.
• Medicinal Chemistry: A valuable tool compound for structure-activity relationship (SAR) studies to optimize potency and pharmacokinetic properties.
• Anti-infective Drug Development: Investigated as a precursor for potential new classes of antibiotics and antiparasitic drugs.
• Biochemical Research: Employed in enzymatic and receptor-binding assays to study interaction mechanisms at a molecular level.
• Reference Standard: Utilized as a high-purity analytical standard for quality control and method validation in API manufacturing.

Basic Information

Product Name	(4S)-4,9-Bis(Acetyloxy)-10-[(Acetyloxy)Methyl]-4-Ethyl-1H-Pyrano[3',4':6,7]Indolizino[1,2-B]Quinoline-3,14(4H,12H)-Dione
CAS No.	1304788-27-9
Molecular Formula	C31H27NO9
Molecular Weight	557.55 g/mol
Synonyms	4,9,10-Triacetyl-4-ethyl-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione; (4S)-4-Ethyl-4,9,10-tris(acetyloxy)-1H,4H,12H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione; NSC 760467; 4-Ethyl-4,9,10-tris(acetoxy)-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione; (S)-4-Ethyl-4,9,10-triacetoxypyranoindolizinoquinolinedione; TAS-103 derivative; Indolizinoquinoline triacetate; 1304788-27-9
EINECS	Contact for details

Quality Control

Our (4S)-4,9-Bis(Acetyloxy)-10-[(Acetyloxy)Methyl]-4-Ethyl-1H-Pyrano[3',4':6,7]Indolizino[1,2-B]Quinoline-3,14(4H,12H)-Dione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with research-grade specifications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and support your regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.