Description

2-Aza-Spiro[3.5]Nonane Hydrochloride is a high-value, nitrogen-containing spirocyclic building block essential for modern pharmaceutical and agrochemical research. Its unique constrained spirocyclic scaffold is prized for modulating the physicochemical properties and biological activity of novel compounds. This intermediate is primarily utilized by medicinal chemists and process development scientists in the synthesis of new chemical entities, particularly for central nervous system (CNS) and other therapeutic targets.

Application

• Pharmaceutical Intermediate: A key building block in the research and development of novel active pharmaceutical ingredients (APIs), especially for neurological and psychiatric disorders.
• Medicinal Chemistry: Used to introduce a rigid, three-dimensional spirocyclic amine moiety into drug candidates to improve selectivity, metabolic stability, and membrane permeability.
• Agrochemical Synthesis: Serves as a precursor in the development of new herbicides, fungicides, and insecticides with novel modes of action.
• Chemical Biology Probes: Employed in the synthesis of tool compounds and probes for studying enzyme function and biological pathways.
• Ligand Development: Used in creating novel ligands for catalysis and receptor binding studies in academic and industrial research settings.

Basic Information

Product Name	2-Aza-Spiro[3.5]Nonane Hydrochloride
CAS No.	1303968-07-1
Molecular Formula	C8H16ClN
Molecular Weight	161.67 g/mol
Synonyms	2-Azaspiro[3.5]nonane hydrochloride; 2-Aza-spiro[3.5]nonane HCl; 2-Azaspiro[3.5]nonane, hydrochloride; 2-Aza-spiro[3.5]nonane monohydrochloride; Azaspiro[3.5]nonane hydrochloride; Spiro[cyclopentane-1,3'-pyrrolidine] hydrochloride; 1-Azaspiro[4.4]nonane hydrochloride (incorrect but common misnomer)
EINECS	Contact for details

Quality Control

Our 2-Aza-Spiro[3.5]Nonane Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all relevant specifications. Our quality commitment supports applications requiring material of pharmaceutical intermediate grade.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.