Description

n-(2-Aminoethyl)-3-(2,5-Dioxo-2,5-Dihydro-1H-Pyrrol-1-Yl)Propanamide 2,2,2-Trifluoroacetate is a high-purity chemical intermediate featuring a reactive maleimide group and a primary amine, making it a versatile linker for bioconjugation and advanced material synthesis. Its primary value lies in enabling the site-specific attachment of biomolecules, peptides, or other functional moieties under mild conditions. This compound is essential for researchers and manufacturers in pharmaceutical development, proteomics, and the production of antibody-drug conjugates (ADCs), where precise and stable covalent bonding is required.

Application

• Antibody-Drug Conjugate (ADC) Linker: A key building block for constructing stable, cleavable, or non-cleavable linkers that connect cytotoxic payloads to monoclonal antibodies.
• Protein and Peptide Labeling: Used for the site-specific modification of cysteine-containing proteins or thiolated peptides via Michael addition.
• Surface Functionalization: Immobilization of biomolecules onto biosensor chips, microarray slides, or nanoparticle surfaces for diagnostic and research applications.
• Cross-linking Reagent: Employed in the synthesis of hydrogels, polymer networks, and biomaterials that require controlled cross-linking density.
• Bioconjugation Kit Component: Supplied as a critical reagent in kits for labeling antibodies, enzymes, or other proteins with fluorophores, biotin, or other tags.
• Solid-Phase Peptide Synthesis (SPPS): Serves as a specialized building block for introducing maleimide functionality directly into synthetic peptide chains.

Basic Information

Product Name	n-(2-Aminoethyl)-3-(2,5-Dioxo-2,5-Dihydro-1H-Pyrrol-1-Yl)Propanamide 2,2,2-Trifluoroacetate
CAS No.	1301739-85-4
Molecular Formula	C11H14F3N3O5
Molecular Weight	325.24 g/mol
Synonyms	N-(2-Aminoethyl)maleimide trifluoroacetate; 2,5-Dioxo-2,5-dihydro-1H-pyrrole-1-propanamide, N-(2-aminoethyl)-, 2,2,2-trifluoroacetate; Maleimidopropionic acid 2-aminoethylamide TFA salt; Amino-PEG2-maleimide TFA; 3-Maleimidopropionamidoethylamine trifluoroacetate; N-(2-Aminoethyl)-3-maleimidopropionamide TFA salt; 1-[3-[(2-Aminoethyl)amino]-3-oxopropyl]-1H-pyrrole-2,5-dione trifluoroacetate
EINECS	Contact for details

Quality Control

Our n-(2-Aminoethyl)-3-(2,5-Dioxo-2,5-Dihydro-1H-Pyrrol-1-Yl)Propanamide 2,2,2-Trifluoroacetate is manufactured under strict quality systems to ensure batch-to-batch consistency for critical research and GMP-grade applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to stringent in-house specifications aligned with the needs of pharmaceutical development, and can provide material with custom purity grades upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This compound is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.