Description

4-Chloro-7-(3,5-Dimethylisoxazol-4-Yl)-6-Methoxyquinoline-3-Carboxamide is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. This compound is valued for its role as a key synthetic building block in the development of novel therapeutic agents, particularly kinase inhibitors. It is primarily sought after by pharmaceutical R&D departments, fine chemical manufacturers, and contract research organizations (CROs) engaged in drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of targeted small-molecule drugs, especially kinase inhibitors for oncology and inflammatory diseases.
• Drug Discovery & Medicinal Chemistry: Serves as a core scaffold for structure-activity relationship (SAR) studies and the generation of compound libraries for high-throughput screening.
• Process Research & Development (PR&D): Used in the optimization and scale-up of synthetic routes for Active Pharmaceutical Ingredients (APIs) under Good Manufacturing Practice (GMP) guidelines.
• Biochemical Research: Employed as a tool compound or a ligand in biochemical assays to study enzyme function and cellular signaling pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to partners requiring bespoke, high-quality building blocks for proprietary synthesis projects.

Basic Information

Product Name	4-Chloro-7-(3,5-Dimethylisoxazol-4-Yl)-6-Methoxyquinoline-3-Carboxamide
CAS No.	1300031-57-5
Molecular Formula	C₁₆H₁₄ClN₃O₃
Molecular Weight	331.75 g/mol
Synonyms	4-Chloro-7-(3,5-dimethyl-4-isoxazolyl)-6-methoxy-3-quinolinecarboxamide; 4-Chloro-7-(3,5-dimethylisoxazol-4-yl)-6-methoxyquinoline-3-carboxylic acid amide; 1300031-57-5; Quinoline-3-carboxamide, 4-chloro-7-(3,5-dimethyl-4-isoxazolyl)-6-methoxy-; 4-Chloro-6-methoxy-7-(3,5-dimethylisoxazol-4-yl)quinoline-3-carboxamide
EINECS	Contact for details

Quality Control

Our 4-Chloro-7-(3,5-Dimethylisoxazol-4-Yl)-6-Methoxyquinoline-3-Carboxamide is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant industry standards and can support development toward cGMP-grade material upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 97.0%
Purity (HPLC Area %)	≥ 98.0%
Single Maximum Impurity	≤ 1.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.