Description

4-(4-Trifluoromethyl-Pyridin-2-Yl)-Benzoic Acid is a high-value, fluorinated aromatic building block that combines a benzoic acid moiety with a trifluoromethyl-substituted pyridine ring. This structure is critical for imparting enhanced metabolic stability, lipophilicity, and binding affinity in advanced molecular design. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients, particularly in drug discovery programs targeting kinases and other biological receptors.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Used in the synthesis of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Material Science Precursor: Serves as a building block for creating specialty polymers, liquid crystals, and organic electronic materials requiring specific fluorinated aromatic structures.
• Chemical Biology & Proteomics: Employed in the design and synthesis of molecular probes, tags, and linkers for studying protein-ligand interactions.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences industry.

Basic Information

Product Name	4-(4-Trifluoromethyl-Pyridin-2-Yl)-Benzoic Acid
CAS No.	1299607-71-8
Molecular Formula	C13H8F3NO2
Molecular Weight	267.21 g/mol
Synonyms	[2-(4-Carboxyphenyl)-4-pyridinyl]trifluoromethane; 4-[4-(Trifluoromethyl)-2-pyridinyl]benzoic Acid; 2-(4-Carboxyphenyl)-4-(trifluoromethyl)pyridine; Benzoic acid, 4-[4-(trifluoromethyl)-2-pyridinyl]-; 4-(4-Trifluoromethyl-2-pyridyl)benzoic Acid
EINECS	Contact for details

Quality Control

Our production of 4-(4-Trifluoromethyl-Pyridin-2-Yl)-Benzoic Acid adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure consistency and compliance with client specifications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and organic solvents. The container must be kept tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.