Description

tert-Butyl (1S,3R)-3-Aminocyclohexylcarbamate is a chiral, protected amino acid derivative of significant importance in advanced organic synthesis. This high-purity building block is critical for the development of novel pharmaceutical compounds, particularly in the synthesis of complex active pharmaceutical ingredients (APIs) and peptide mimetics. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in drug discovery and process development, where precise stereochemistry and reliable quality are paramount.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug candidates, particularly for central nervous system (CNS) and antiviral targets.
• Peptidomimetics & PROTACs: Serves as a crucial building block for constructing peptide-like molecules and Proteolysis Targeting Chimeras (PROTACs) due to its protected amine and cyclohexyl backbone.
• Asymmetric Synthesis: Used in catalytic asymmetric reactions to introduce the (1S,3R)-3-aminocyclohexyl moiety with high enantiomeric and diastereomeric purity.
• Medicinal Chemistry Research: Enables structure-activity relationship (SAR) studies by providing a versatile, stereochemically defined scaffold for library synthesis.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis organizations (CSOs) and CDMOs producing GMP-grade intermediates for clinical trials.

Basic Information

Product Name	tert-Butyl (1S,3R)-3-Aminocyclohexylcarbamate
CAS No.	1298101-47-9
Molecular Formula	C11H22N2O2
Molecular Weight	214.31 g/mol
Synonyms	(1S,3R)-3-[(tert-Butoxycarbonyl)amino]cyclohexanamine; (1S,3R)-3-Amino-N-Boc-cyclohexylamine; tert-Butyl N-[(1S,3R)-3-aminocyclohexyl]carbamate; (1S,3R)-3-(Boc-amino)cyclohexylamine; (1R,3S)-3-Aminocyclohexylcarbamic acid tert-butyl ester; Boc-(1S,3R)-3-Acah; (1S,3R)-Boc-DACH; trans-N-Boc-1,3-diaminocyclohexane (stereospecific)
EINECS	Contact for details

Quality Control

Our tert-Butyl (1S,3R)-3-Aminocyclohexylcarbamate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity. Production adheres to cGMP guidelines where applicable, and all materials are fully characterized using advanced analytical techniques. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles is provided with each shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.