Description

o-Pivaloylhydroxylamine Triflate is a specialized organic salt, a trifluoromethanesulfonate derivative of pivaloylhydroxylamine, with the CAS registry number 1293990-73-4. This compound serves as a high-value building block and reagent in advanced synthetic chemistry, prized for its role in introducing protected hydroxylamine functionalities. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in the synthesis of complex molecules, including active pharmaceutical ingredients (APIs) and agrochemical intermediates.

Application

• Pharmaceutical Intermediate: Key reagent in the synthesis of novel drug candidates, particularly those requiring hydroxylamine or oxime functional groups.
• Peptide & Protein Modification: Used for selective chemical modification of amino acid side chains in bioconjugation chemistry.
• Agrochemical Synthesis: Building block for creating advanced herbicides, fungicides, and plant growth regulators.
• Material Science Research: Employed in the development of functional polymers and specialty coatings with tailored properties.
• Cross-coupling Reactions: Acts as an electrophilic amination reagent in palladium-catalyzed cross-coupling processes.
• Academic & Process Chemistry: A valuable tool for methodological development and scale-up synthesis in research laboratories.

Basic Information

Product Name	o-Pivaloylhydroxylamine Triflate
CAS No.	1293990-73-4
Molecular Formula	C6H12F3NO4S
Molecular Weight	251.22 g/mol
Synonyms	Pivaloylhydroxylamine Trifluoromethanesulfonate; 2,2-Dimethylpropanoylhydroxylamine Triflate; N-(Trifluoromethylsulfonyloxy)pivalamide; O-Pivaloylhydroxylamine Trifluoromethanesulfonic Acid Salt; Hydroxylamine, O-(2,2-dimethyl-1-oxopropoxy)-, trifluoromethanesulfonate (1:1); Trifluoromethanesulfonic acid, compd. with O-(2,2-dimethyl-1-oxopropoxy)hydroxylamine (1:1)
EINECS	Contact for details

Quality Control

Our o-Pivaloylhydroxylamine Triflate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content to ensure compliance with stringent specifications. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment. We support development and cGMP-grade requirements for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.