Description

3-Quinolinecarboxylic Acid, 1-Cyclopropyl-6-Fluoro-1,4-Dihydro-8-Hydroxy-7-[(4Ar,7Ar)-Octahydro-6H-Pyrrolo[3,4-B]Pyridin-6-Yl]-4-Oxo-, Rel- is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is of significant commercial importance for its role in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in the antibacterial and quinolone therapeutic classes. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development and scale-up of next-generation antibiotic drugs.

Application

• Key Intermediate for Antibacterial API Synthesis: Serves as a critical building block in the production of advanced fluoroquinolone and related antibiotic compounds.
• Pharmaceutical Research & Development (R&D): Used in medicinal chemistry for the design, optimization, and discovery of new drug candidates targeting bacterial infections.
• Process Chemistry & Scale-Up: Employed in pilot plants and commercial manufacturing to develop robust and efficient synthetic routes for target APIs.
• Reference Standard: Can be utilized as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) producing specialized drug substances for clinical trials and commercial supply.

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 1-Cyclopropyl-6-Fluoro-1,4-Dihydro-8-Hydroxy-7-[(4Ar,7Ar)-Octahydro-6H-Pyrrolo[3,4-B]Pyridin-6-Yl]-4-Oxo-, Rel-
CAS No.	1293488-61-5
Molecular Formula	C20H22FN3O4
Molecular Weight	387.41 g/mol
Synonyms	Rel-1-Cyclopropyl-6-fluoro-1,4-dihydro-8-hydroxy-7-[(4aR,7aR)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-3-quinolinecarboxylic acid; (rel)-1-Cyclopropyl-6-fluoro-8-hydroxy-7-((4aR,7aR)-octahydro-1H-pyrrolo[3,4-b]pyridin-6(2H)-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; Advanced Quinolone Intermediate; Antibacterial API Intermediate; Octahydropyrrolopyridine quinoline derivative
EINECS	Contact for details

Quality Control

Our 3-Quinolinecarboxylic Acid intermediate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for pharmaceutical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP (current Good Manufacturing Practice) guidelines where applicable, and our quality protocols are designed to meet the stringent requirements of pharmaceutical R&D and production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). The product is light-sensitive (store away from light). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.