Description

2,2,2-Trifluoro-1-(6-Nitro-3,4-Dihydro-2H-Quinolin-1-Yl)Ethanone is a high-value, fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in the strategic combination of a quinoline scaffold with a reactive trifluoroacetyl ketone group, enabling precise molecular modifications. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and infectious diseases.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and insecticides, where the fluorine atoms and nitro group can enhance biological activity and environmental stability.
• Material Science: Acts as a specialized monomer or cross-linking agent for synthesizing advanced polymers with unique optical or electronic properties.
• Chemical Biology Probe: Utilized in the design of molecular probes and tags for studying enzyme mechanisms and protein interactions due to its reactive ketone functionality.
• Fluorine Chemistry: A valuable substrate for exploring new fluorination reactions and creating libraries of fluorinated compounds for screening in various discovery programs.

Basic Information

Product Name	2,2,2-Trifluoro-1-(6-Nitro-3,4-Dihydro-2H-Quinolin-1-Yl)Ethanone
CAS No.	1290608-21-7
Molecular Formula	C₁₁H₉F₃N₂O₃
Molecular Weight	274.20 g/mol
Synonyms	1-(6-Nitro-3,4-dihydro-2H-quinolin-1-yl)-2,2,2-trifluoroethanone; 2,2,2-Trifluoro-1-(6-nitro-1,2,3,4-tetrahydroquinolin-1-yl)ethan-1-one; 6-Nitro-1-(trifluoroacetyl)-1,2,3,4-tetrahydroquinoline; 1-(Trifluoroacetyl)-6-nitro-1,2,3,4-tetrahydroquinoline; 1290608-21-7; TQNE; TFNE.
EINECS	Contact for details

Quality Control

Our 2,2,2-Trifluoro-1-(6-Nitro-3,4-Dihydro-2H-Quinolin-1-Yl)Ethanone is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We support compliance with REACH and other relevant global regulatory frameworks for chemical substances.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This compound is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive); therefore, containers should be kept sealed under an inert atmosphere if specified for long-term storage.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.