Description

(S)-3-(6-Chloro-Pyrimidin-4-Ylamino)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is a high-purity chiral building block and advanced pharmaceutical intermediate of significant commercial importance. Its value lies in its role as a key synthon for the synthesis of complex, biologically active molecules, particularly in medicinal chemistry. This compound is essential for research and development chemists and process scale-up teams in the pharmaceutical and biotechnology industries, where it is used to construct novel drug candidates.

Application

• Pharmaceutical Intermediate: A critical chiral precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other targeted therapies.
• Medicinal Chemistry Research: Serves as a versatile building block for constructing compound libraries in drug discovery programs, enabling structure-activity relationship (SAR) studies.
• Process Chemistry & Scale-Up: Used in the development and optimization of scalable synthetic routes for candidate drugs during clinical development phases.
• Bioconjugation & Probe Development: The reactive chloro-pyrimidine moiety and protected amine functionality make it suitable for creating biochemical probes and targeted conjugates.
• Asymmetric Synthesis: Leverages the chiral (S)-pyrrolidine center for the stereoselective construction of complex molecular architectures.

Basic Information

Item	Details
Product Name	(S)-3-(6-Chloro-Pyrimidin-4-Ylamino)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1289585-01-8
Molecular Formula	C14H20ClN5O2
Molecular Weight	325.79 g/mol
Synonyms	(S)-tert-Butyl 3-((6-chloropyrimidin-4-yl)amino)pyrrolidine-1-carboxylate; (S)-1-Boc-3-((6-chloro-4-pyrimidinyl)amino)pyrrolidine; (S)-3-[(6-Chloro-4-pyrimidinyl)amino]-1-(tert-butoxycarbonyl)pyrrolidine; (S)-N-(6-Chloropyrimidin-4-yl)-1-Boc-pyrrolidin-3-amine; 1-Boc-3-(6-chloro-pyrimidin-4-ylamino)-(S)-pyrrolidine; (S)-3-(6-Chloro-4-pyrimidinylamino)pyrrolidine-1-carboxylic acid tert-butyl ester; BOC-(S)-3-((6-Chloro-4-pyrimidinyl)amino)pyrrolidine
EINECS	Contact for details

Quality Control

Our (S)-3-(6-Chloro-Pyrimidin-4-Ylamino)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, purity, and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture uptake, which can affect stability and handling properties. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.