Description

(R)-3-(4-Fluoro-Phenylsulfanyl)-Pyrrolidine Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate. This compound is of significant value for the development of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and metabolic disorder research. It is primarily needed by pharmaceutical R&D laboratories, contract research and manufacturing organizations (CROs/CMOs), and fine chemical suppliers serving the life sciences sector.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of potential drug candidates targeting neurological receptors.
• Asymmetric Synthesis: Used as a precursor or catalyst ligand in stereoselective chemical transformations.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies in drug discovery programs.
• Reference Standard: Employed as an analytical standard for quality control and method development in API manufacturing.
• Biochemical Tool Compound: Used in vitro to study biological pathways and enzyme interactions.

Basic Information

Product Name	(R)-3-(4-Fluoro-Phenylsulfanyl)-Pyrrolidine Hydrochloride
CAS No.	1289584-92-4
Molecular Formula	C10H12FNS•HCl
Molecular Weight	233.73 g/mol (Free base: 197.27 g/mol)
Synonyms	(R)-3-[(4-Fluorophenyl)thio]pyrrolidine hydrochloride; (3R)-3-[(4-Fluorophenyl)sulfanyl]pyrrolidine hydrochloride; (R)-3-(p-Fluorophenylthio)pyrrolidine HCl; Pyrrolidine, 3-[(4-fluorophenyl)thio]-, (3R)-, hydrochloride; (R)-3-(4-Fluorophenylsulfanyl)pyrrolidine HCl; (R)-3-(4-Fluorobenzenesulfanyl)pyrrolidine hydrochloride
EINECS	Contact for details

Quality Control

Our (R)-3-(4-Fluoro-Phenylsulfanyl)-Pyrrolidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with research and development grade standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥97.0%
Chiral Purity (Chiral HPLC)	≥98.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.