Description

H2N-Peg6-Tbu CAS NO 1286281-32-0 is a high-purity, heterobifunctional polyethylene glycol (PEG) derivative featuring a primary amine group and a tert-butyl ester-protected carboxylic acid. This compound is a critical building block in bioconjugation and pharmaceutical development, enabling the precise, site-specific linkage of bioactive molecules. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors for creating PEGylated therapeutics, diagnostic probes, and functionalized biomaterials.

Application

• Bioconjugation Linker: Serves as a versatile spacer and linker for coupling peptides, proteins, antibodies, and other biomolecules.
• PEGylation Reagent: Used to modify therapeutic proteins and peptides to enhance solubility, reduce immunogenicity, and prolong circulation half-life.
• Drug Delivery Systems: A key intermediate in the synthesis of targeted drug delivery conjugates, such as antibody-drug conjugates (ADCs).
• Diagnostic Probe Synthesis: Facilitates the attachment of dyes, fluorophores, or chelating agents to targeting molecules for imaging applications.
• Surface Functionalization: Used to modify nanoparticles, quantum dots, and other material surfaces with amine-reactive groups for subsequent bioligand attachment.
• Cross-linking Agent: Employed in the preparation of hydrogels and polymer networks with controlled chemical functionality.

Basic Information

Product Name	H2N-Peg6-Tbu
CAS No.	1286281-32-0
Molecular Formula	C25H51N1O9
Molecular Weight	509.68 g/mol
Synonyms	6-Amino-3,6,9,12,15,18-hexaoxahenicosan-21-oic acid tert-butyl ester; Amino-PEG6-t-butyl ester; H2N-PEG6-COOtBu; tert-Butyl 19-amino-4,7,10,13,16,19-hexaoxanonadecanoate; Amine-PEG6-acid t-butyl ester; Amino-PEG6-tBu ester; 1-Amino-3,6,9,12,15,18-hexaoxahenicosan-21-oic acid tert-butyl ester; NH2-PEG6-COOtBu
EINECS	Contact for details

Quality Control

Our H2N-Peg6-Tbu is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance for sensitive research and development applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (HPLC/MS)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.