Description

1-(2,6-Difluorobenzyl)Piperidin-4-Aminedihydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its dihydrochloride salt form. This compound is of significant value in medicinal chemistry for its role as a key building block in the synthesis of active pharmaceutical ingredients (APIs). It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly within central nervous system (CNS) and oncology research pipelines.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of complex drug candidates and Active Pharmaceutical Ingredients (APIs).
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Biochemical Tool Compound: Used in pharmacological assays and as a reference standard for analytical method development and validation.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of clinical trial materials.
• Academic Research: Utilized in university and institutional labs for fundamental research in organic synthesis and pharmacology.

Basic Information

Product Name	1-(2,6-Difluorobenzyl)Piperidin-4-Aminedihydrochloride
CAS No.	1286265-20-0
Molecular Formula	C12H17Cl2F2N2
Molecular Weight	298.18 g/mol
Synonyms	1-[(2,6-Difluorophenyl)methyl]-4-piperidinamine dihydrochloride; 4-Amino-1-(2,6-difluorobenzyl)piperidine dihydrochloride; 1-(2,6-Difluorobenzyl)-4-aminopiperidine dihydrochloride; 1-(2,6-Difluorobenzyl)piperidin-4-amine hydrochloride (1:2); 1286265-20-0; UNII-3V8Q5V7F6I; 3V8Q5V7F6I
EINECS	Contact for details

Quality Control

Our 1-(2,6-Difluorobenzyl)Piperidin-4-Aminedihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with the standards expected for pharmaceutical development, supporting both research and pre-clinical manufacturing needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.