Description

(R)-n-(3-Fluorobenzyl)Piperidin-3-Aminedihydrochloride is a high-purity chiral amine derivative, specifically a dihydrochloride salt, designed for advanced pharmaceutical research and development. This compound serves as a critical building block or intermediate in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting neurological and psychiatric disorders. It is essential for medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries who require reliable, high-quality intermediates to accelerate drug discovery pipelines and ensure scalable synthesis.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel drug candidates, particularly for central nervous system (CNS) targets.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in the multi-step synthesis of potential therapeutic agents, leveraging its piperidine and fluorobenzyl pharmacophores.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to optimize potency and selectivity of lead compounds.
• Process Chemistry & Scale-Up: Serves as a standardized starting material or intermediate for developing robust and cost-effective manufacturing routes for APIs.
• Biochemical Tool Compound: Potentially used in vitro to study enzyme inhibition or receptor binding mechanisms in pharmacological assays.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development and quality control in pharmaceutical production.

Basic Information

Product Name	(R)-n-(3-Fluorobenzyl)Piperidin-3-Aminedihydrochloride
CAS No.	1286209-24-2
Molecular Formula	C12H18F N2 · 2HCl
Molecular Weight	279.20 g/mol (Free base: 206.28 g/mol)
Synonyms	(R)-1-[(3-Fluorophenyl)methyl]-3-piperidinamine dihydrochloride; (R)-N-[(3-Fluorophenyl)methyl]-3-piperidinamine dihydrochloride; (R)-3-Amino-1-(3-fluorobenzyl)piperidine dihydrochloride; (R)-1-(3-Fluorobenzyl)piperidin-3-amine dihydrochloride; (3R)-1-[(3-Fluorophenyl)methyl]-3-piperidinamine dihydrochloride; (R)-N-(3-Fluorobenzyl)-3-aminopiperidine dihydrochloride
EINECS	Contact for details

Quality Control

Our (R)-n-(3-Fluorobenzyl)Piperidin-3-Aminedihydrochloride is manufactured under a quality management system and undergoes rigorous analytical testing to ensure it meets the stringent requirements for pharmaceutical intermediates. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant ICH guidelines for stability and impurity characterization to support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥98.0% (anhydrous basis)
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual unknown impurity ≤0.5%; Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.