Description

(S)-1-(Cyclobutylmethyl)Pyrrolidin-3-Amine Dihydrochloride is a high-purity chiral amine building block and pharmaceutical intermediate. This compound matters for its critical role in the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of central nervous system (CNS) and other therapeutic agents. Pharmaceutical R&D laboratories and fine chemical manufacturers need it for constructing complex molecules where stereochemical purity is essential for biological activity.

Application

• Pharmaceutical Intermediate: Key chiral building block in the synthesis of novel drug candidates, especially for neurological and psychiatric disorders.
• Active Pharmaceutical Ingredient (API) Development: Used in research and process development for new therapeutic agents.
• Asymmetric Synthesis: Serves as a chiral amine source or catalyst ligand in stereoselective chemical reactions.
• Medicinal Chemistry Research: A valuable scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Reference Standard: Used as an analytical standard for quality control and method development in pharmaceutical analysis.
• Chemical Biology Probes: Can be utilized in the development of molecular probes for studying biological pathways and target engagement.

Basic Information

Product Name	(S)-1-(Cyclobutylmethyl)Pyrrolidin-3-Amine Dihydrochloride
CAS No.	1286209-18-4
Molecular Formula	C9H20N2 • 2HCl
Molecular Weight	237.19 g/mol (free base: 154.27 g/mol)
Synonyms	(S)-1-(Cyclobutylmethyl)-3-aminopyrrolidine dihydrochloride; (3S)-1-(Cyclobutylmethyl)pyrrolidin-3-amine dihydrochloride; (S)-3-Amino-1-(cyclobutylmethyl)pyrrolidine dihydrochloride; (S)-1-(Cyclobutylmethyl)-3-pyrrolidinamine dihydrochloride; (S)-1-Cyclobutylmethyl-3-aminopyrrolidine dihydrochloride; (S)-1-(Cyclobutylmethyl)pyrrolidin-3-amine hydrochloride (1:2); (S)-1-(Cyclobutylmethyl)azetidin-3-amine dihydrochloride (common misnomer based on structure)
EINECS	Contact for details

Quality Control

Our (S)-1-(Cyclobutylmethyl)Pyrrolidin-3-Amine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.