Description

(R)-1-Neopentylpyrrolidin-3-Amine Dihydrochloride is a high-purity chiral amine building block, essential for the synthesis of complex pharmaceutical intermediates and active pharmaceutical ingredients (APIs). Its value lies in providing a stereochemically defined, functionalized pyrrolidine core, which is a privileged scaffold in medicinal chemistry for modulating biological activity and pharmacokinetic properties. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for creating novel therapeutic agents and advanced materials.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of novel drug candidates targeting central nervous system (CNS) disorders, antiviral agents, and other therapeutic areas.
• Asymmetric Catalyst Ligand Precursor: Serves as a starting material for developing novel chiral ligands used in asymmetric synthesis to create enantiomerically pure compounds.
• Agrochemical Research: Used in the research and development of new, more effective pesticides and herbicides with specific chiral configurations.
• Chemical Biology Probe Development: Utilized to create molecular probes for studying enzyme mechanisms and protein-ligand interactions in biological systems.
• Fine Chemical Synthesis: Employed in custom synthesis and contract manufacturing for producing high-value, specialty chemicals with specific stereochemical requirements.

Basic Information

Item	Detail
Product Name	(R)-1-Neopentylpyrrolidin-3-Amine Dihydrochloride
CAS No.	1286209-03-7
Molecular Formula	C9H20N2 • 2HCl
Molecular Weight	225.19 g/mol (Free base: 156.27 g/mol)
Synonyms	(R)-1-(2,2-Dimethylpropyl)pyrrolidin-3-amine dihydrochloride; (R)-3-Amino-1-neopentylpyrrolidine dihydrochloride; (R)-1-Neopentyl-3-aminopyrrolidine dihydrochloride; (R)-1-(tert-Butylmethyl)pyrrolidin-3-amine dihydrochloride; (R)-1-Neopentylpyrrolidin-3-amine hydrochloride (1:2); (3R)-1-(2,2-Dimethylpropyl)-3-pyrrolidinamine dihydrochloride
EINECS	Contact for details

Quality Control

Our (R)-1-Neopentylpyrrolidin-3-Amine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity (typically ≥97% by HPLC), chiral excess (typically ≥98% ee), and impurity profiles are provided and available upon request to support your regulatory and R&D documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation and ensure long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.