Description

(R)-1-[(Tetrahydro-2H-Pyran-4-Yl)Methyl]Pyrrolidin-3-Amine Dihydrochloride is a high-purity chiral amine building block essential for advanced pharmaceutical research and development. This compound serves as a critical intermediate in the synthesis of complex molecules, offering a defined stereocenter for creating enantiomerically pure active pharmaceutical ingredients (APIs). It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and development of novel therapeutic agents, particularly in central nervous system (CNS) and metabolic disorder drug candidates.
• Asymmetric Synthesis: Used as a building block in stereoselective synthesis to introduce the (R)-configured pyrrolidin-3-amine moiety into target molecules.
• Ligand and Catalyst Development: Serves as a precursor for creating chiral ligands and organocatalysts used in enantioselective transformations.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological pathways and target engagement.
• Process Chemistry: Utilized in route scouting and scale-up activities for the commercial manufacturing of chiral APIs under GMP conditions.
• Academic Research: A valuable reagent for universities and research institutes exploring new synthetic methodologies and bioactive compound libraries.

Basic Information

Product Name	(R)-1-[(Tetrahydro-2H-Pyran-4-Yl)Methyl]Pyrrolidin-3-Amine Dihydrochloride
CAS No.	1286207-98-4
Molecular Formula	C10H22Cl2N2O
Molecular Weight	257.20 g/mol
Synonyms	(R)-1-((Tetrahydro-2H-pyran-4-yl)methyl)pyrrolidin-3-amine dihydrochloride; (3R)-1-[(Oxan-4-yl)methyl]pyrrolidin-3-amine dihydrochloride; (R)-3-Amino-1-((tetrahydro-2H-pyran-4-yl)methyl)pyrrolidine dihydrochloride; (R)-1-(Tetrahydro-2H-pyran-4-ylmethyl)pyrrolidin-3-amine dihydrochloride; Pyrrolidin-3-amine, 1-[(tetrahydro-2H-pyran-4-yl)methyl]-, (3R)-, dihydrochloride; UNII-7J1X5Z8B6C; 7J1X5Z8B6C; (R)-1-(Tetrahydro-2H-pyran-4-ylmethyl)-3-aminopyrrolidine dihydrochloride
EINECS	Contact for details

Quality Control

Our (R)-1-[(Tetrahydro-2H-Pyran-4-Yl)Methyl]Pyrrolidin-3-Amine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, confirming identity, purity, and enantiomeric excess.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.