Description

(R)-1-(2-Bromobenzyl)Pyrrolidin-3-Aminedihydrochloride is a high-purity chiral amine derivative and a key pharmaceutical intermediate. This compound matters for its role as a critical building block in the synthesis of complex, biologically active molecules, enabling the development of targeted therapeutics. It is primarily needed by research institutions and pharmaceutical companies engaged in medicinal chemistry, process development, and the production of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A crucial chiral building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for developing new therapeutic agents.
• Process Chemistry & Scale-up: Serves as a starting material or intermediate in the development and optimization of commercial-scale API manufacturing processes.
• Asymmetric Synthesis: Utilized in chiral pool synthesis and the construction of complex molecules requiring specific stereochemistry.
• Reference Standard: Employed as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.
• Bioconjugation & Probe Development: Potential use in creating chemical probes or conjugates for biochemical and pharmacological studies.

Basic Information

Product Name	(R)-1-(2-Bromobenzyl)Pyrrolidin-3-Aminedihydrochloride
CAS No.	1286207-54-2
Molecular Formula	C11H16BrN2·2HCl
Molecular Weight	352.09 g/mol (for dihydrochloride salt)
Synonyms	(3R)-1-[(2-Bromophenyl)methyl]pyrrolidin-3-amine dihydrochloride; (R)-1-(2-Bromobenzyl)-3-aminopyrrolidine dihydrochloride; (R)-1-(2-Bromobenzyl)pyrrolidin-3-amine hydrochloride (1:2); 1-(2-Bromobenzyl)-3-aminopyrrolidine (R)-enantiomer dihydrochloride; (R)-1-(2-Bromo-benzyl)-pyrrolidin-3-ylamine dihydrochloride; 1286207-54-2; (R)-1-(2-Bromobenzyl)-3-pyrrolidinamine dihydrochloride
EINECS	Contact for details

Quality Control

Our (R)-1-(2-Bromobenzyl)Pyrrolidin-3-Aminedihydrochloride is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area. Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption. Recommended long-term storage at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.