Description

7'-Fluoro-2',3'-Dihydro-1'H-Spiro[Cyclobutane-1,4'-Isoquinoline] is a high-value, fluorinated spirocyclic building block of significant interest in modern pharmaceutical and agrochemical research. Its unique molecular architecture, featuring a fused isoquinoline and cyclobutane ring system, provides a rigid three-dimensional scaffold for designing novel bioactive compounds. This advanced intermediate is primarily utilized by R&D chemists and process development scientists in the life sciences sector seeking to enhance the potency, selectivity, and metabolic stability of new drug candidates.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel small molecule therapeutics targeting central nervous system (CNS) disorders, oncology, and inflammatory diseases.
• Medicinal Chemistry Research: Serves as a privileged scaffold in fragment-based drug discovery and library synthesis for structure-activity relationship (SAR) studies.
• Agrochemical Development: Used in the research and development of new-generation pesticides and herbicides, where the fluorine atom and spiro structure can improve bioactivity and environmental profile.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Material Science Research: Potential precursor for developing specialty chemicals and advanced organic materials with specific electronic or photophysical properties.

Basic Information

Product Name	7'-Fluoro-2',3'-Dihydro-1'H-Spiro[Cyclobutane-1,4'-Isoquinoline]
CAS No.	1283718-61-5
Molecular Formula	C₁₂H₁₂FN
Molecular Weight	189.23 g/mol
Synonyms	7'-Fluoro-1'H-spiro[cyclobutane-1,4'-isoquinoline]-2',3'-dihydro; 7-Fluoro-2,3-dihydro-1H-spiro[cyclobutane-1,4'-isoquinoline]; 7-Fluoro-1,2,3,4-tetrahydrospiro[cyclobutane-1,4'-isoquinoline]; Spiro[cyclobutane-1,4'-isoquinoline], 7'-fluoro-2',3'-dihydro-; 1283718-61-5; 7'-Fluoro-2',3'-dihydrospiro[cyclobutane-1,1'(2'H)-isoquinoline]; 7-Fluoro-3,4-dihydro-1H-spiro[cyclobutane-1,2'-isoquinoline] (tautomer).
EINECS	Contact for details

Quality Control

Our production of 7'-Fluoro-2',3'-Dihydro-1'H-Spiro[Cyclobutane-1,4'-Isoquinoline] adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot is fully characterized using advanced analytical techniques including NMR, HPLC, and MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound may be light-sensitive (store away from light) and hygroscopic (moisture-sensitive); handle and store under an inert atmosphere such as nitrogen or argon for long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.