Description

3-Acetyl-6-Chloro-4-(3,4-Difluorophenyl)Quinolin-2(1H)-One is a high-purity, advanced pharmaceutical intermediate belonging to the quinolinone class of heterocyclic compounds. This compound is of significant commercial interest for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly within oncology and anti-inflammatory drug discovery pipelines.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of complex drug candidates, especially those targeting kinase inhibition.
• Organic Synthesis Building Block: Used in research and development for constructing more complex quinoline-based molecular architectures.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to optimize the potency and selectivity of new chemical entities.
• Contract Manufacturing (CMO): Supplied to contract manufacturing organizations for scale-up and cGMP production of clinical trial materials.
• Biochemical Research: May be used as a reference standard or probe compound in biochemical assays to study specific biological pathways.

Basic Information

Product Name	3-Acetyl-6-Chloro-4-(3,4-Difluorophenyl)Quinolin-2(1H)-One
CAS No.	1283108-05-3
Molecular Formula	C17H10ClF2NO2
Molecular Weight	333.72 g/mol
Synonyms	3-Acetyl-6-chloro-4-(3,4-difluorophenyl)-1,2-dihydroquinolin-2-one; 3-Acetyl-6-chloro-4-(3,4-difluorophenyl)-2(1H)-quinolinone; 2(1H)-Quinolinone, 3-acetyl-6-chloro-4-(3,4-difluorophenyl)-; 1283108-05-3; 6-Chloro-3-acetyl-4-(3,4-difluorophenyl)-1H-quinolin-2-one
EINECS	Contact for details

Quality Control

Our 3-Acetyl-6-Chloro-4-(3,4-Difluorophenyl)Quinolin-2(1H)-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) detailing specifications such as assay (HPLC), related substances, and residual solvents. Our quality commitment supports applications requiring high standards, including cGMP production for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.