Description

4,4-Difluoro-6-Azaspiro[2.5]Octane Hydrochloride is a high-value, advanced pharmaceutical intermediate featuring a unique spirocyclic and difluorinated structure. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel active pharmaceutical ingredients (APIs) where its scaffold can impart desirable metabolic stability and bioavailability. It is primarily sought after by R&D teams and process chemists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially in central nervous system (CNS) and oncology research.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its spirocyclic and fluorine motifs.
• Agrochemical Synthesis: Serves as a precursor in the development of new-generation pesticides and herbicides with enhanced properties.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological targets and pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and GMP production.
• Academic Research: Employed in university and institutional labs for methodological development and novel heterocyclic chemistry.

Basic Information

Product Name	4,4-Difluoro-6-Azaspiro[2.5]Octane Hydrochloride
CAS No.	1282532-00-6
Molecular Formula	C7H11ClF2N
Molecular Weight	182.62 g/mol
Synonyms	6-Azaspiro[2.5]octane, 4,4-difluoro-, hydrochloride; 4,4-Difluoro-6-azaspiro[2.5]octane HCl; 4,4-Difluoro-6-azaspiro[2.5]octane hydrochloride; 4,4-Difluoro-6-azaspiro[2.5]octane monohydrochloride; 1282532-00-6; 6-Azaspiro[2.5]octane, 4,4-difluoro-, monohydrochloride
EINECS	Contact for details

Quality Control

Our 4,4-Difluoro-6-Azaspiro[2.5]Octane Hydrochloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for demanding R&D and scale-up applications. We provide comprehensive analytical data including HPLC purity, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is supplied with each batch to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) in a desiccator for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.