Description

(2R,4S)-tert-Butyl 4-Amino-2-(Hydroxymethyl)Pyrrolidine-1-Carboxylate Hydrochloride is a high-purity, chiral pyrrolidine derivative that serves as a critical building block in modern organic synthesis. Its value lies in its dual functionalization, providing both a protected amine and a hydroxymethyl group on a stereodefined scaffold, which is essential for constructing complex molecules with high enantiomeric purity. This advanced pharmaceutical intermediate is primarily needed by research institutions and manufacturers in the pharmaceutical and biotechnology sectors for the development of novel active pharmaceutical ingredients (APIs), particularly in areas like protease inhibitors and other small-molecule therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug candidates, especially those targeting viral proteases and neurological disorders.
• Peptidomimetic Research: Used to construct constrained peptide analogs and macrocycles due to its rigid pyrrolidine ring and functional handles.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for developing novel chiral ligands and organocatalysts.
• API Process Development: Employed in route scouting and scale-up processes for new chemical entities (NCEs) under Good Manufacturing Practice (GMP) conditions.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function and protein-protein interactions.
• Custom Synthesis & Contract Manufacturing: A critical component for custom synthesis houses offering specialized, gram-to-kilogram scale manufacturing services.

Basic Information

Item	Details
Product Name	(2R,4S)-tert-Butyl 4-Amino-2-(Hydroxymethyl)Pyrrolidine-1-Carboxylate Hydrochloride
CAS No.	1279039-34-7
Molecular Formula	C10H21N2O3 • HCl
Molecular Weight	252.75 g/mol (Free base: 216.28 g/mol)
Synonyms	1-Boc-4-Amino-2-(hydroxymethyl)pyrrolidine-2R,4S hydrochloride; (2R,4S)-1-(tert-Butoxycarbonyl)-4-amino-2-(hydroxymethyl)pyrrolidine hydrochloride; (2R,4S)-N-Boc-4-Amino-2-hydroxymethylpyrrolidine HCl; (2R,4S)-4-Amino-2-(hydroxymethyl)-1-pyrrolidinecarboxylic acid 1,1-dimethylethyl ester hydrochloride; (2R,4S)-1-Boc-4-Amino-2-hydroxymethylpyrrolidine HCl; (2R,4S)-tert-Butyl 4-amino-2-(hydroxymethyl)-1-pyrrolidinecarboxylate hydrochloride; (2R-cis)-1-(1,1-Dimethylethyl) 4-amino-2-(hydroxymethyl)-1-pyrrolidinecarboxylate hydrochloride
EINECS	Contact for details

Quality Control

Our production of (2R,4S)-tert-Butyl 4-Amino-2-(Hydroxymethyl)Pyrrolidine-1-Carboxylate Hydrochloride adheres to stringent quality protocols suitable for pharmaceutical R&D and development-scale manufacturing. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess and NMR for structural confirmation, to ensure high chemical and chiral purity. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We support development with customized specifications and can align with relevant pharmacopeial guidelines (e.g., ICH Q3A/B) upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under dry conditions to prevent decomposition. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.