Description

4H-Pyrrolo[3,2-B]Pyridine-4-Carboxylic Acid, Octahydro-, 1,1-Dimethylethyl Ester, (3Ar,7Ar)-Rel- is a high-purity, advanced pharmaceutical intermediate with a complex fused bicyclic structure. This compound is of significant value for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular scaffolds. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of new drugs, especially within medicinal chemistry and process R&D for complex heterocyclic targets.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of complex drug candidates, particularly those with pyrrolopyridine or related fused heterocyclic cores.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Process Chemistry Development: Employed in the optimization and scale-up of synthetic routes for new chemical entities (NCEs) under Good Manufacturing Practice (GMP) conditions.
• Active Pharmaceutical Ingredient (API) Synthesis: A key chiral building block for constructing the core structure of potential APIs targeting central nervous system (CNS) disorders, oncology, or other specialized therapeutic areas.
• Chemical Biology Probes: Can be utilized to develop tool compounds for investigating biological pathways and target validation.

Basic Information

Product Name	4H-Pyrrolo[3,2-B]Pyridine-4-Carboxylic Acid, Octahydro-, 1,1-Dimethylethyl Ester, (3Ar,7Ar)-Rel-
CAS No.	1277168-52-1
Molecular Formula	C14H24N2O2
Molecular Weight	252.35 g/mol
Synonyms	rel-(3aR,7aR)-Octahydro-4H-pyrrolo[3,2-b]pyridine-4-carboxylic acid tert-butyl ester; tert-Butyl (3aR,7aR)-octahydro-4H-pyrrolo[3,2-b]pyridine-4-carboxylate; (3aR,7aR)-rel-Octahydro-4H-pyrrolo[3,2-b]pyridine-4-carboxylic acid 1,1-dimethylethyl ester; 1,1-Dimethylethyl (3aR,7aR)-rel-octahydro-4H-pyrrolo[3,2-b]pyridine-4-carboxylate; tert-Butyl octahydro-4H-pyrrolo[3,2-b]pyridine-4-carboxylate (rel-(3aR,7aR)-); Bicyclic pyrrolopyridine tert-butyl ester intermediate.
EINECS	Contact for details

Quality Control

Our 4H-Pyrrolo[3,2-B]Pyridine-4-Carboxylic Acid, Octahydro-, 1,1-Dimethylethyl Ester, (3Ar,7Ar)-Rel- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity and impurity profiling, to ensure it meets the exacting standards required for pharmaceutical R&D and scale-up. Certificates of Analysis (COA) with detailed chromatographic data (HPLC/GC) are provided for every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container sealed to protect this light-sensitive material from degradation and moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.