Description

(9H-Fluoren-9-Yl)Methyl(((1S,3R)-3-(Aminomethyl)Cyclohexyl)Methyl)Carbamate Hydrochloride is a high-purity, protected amine derivative used as a critical building block in advanced organic synthesis. This compound is valued for its role in the controlled introduction of the (1S,3R)-3-(aminomethyl)cyclohexylmethyl moiety into complex molecular architectures. It is primarily required by research institutions and pharmaceutical development companies engaged in the synthesis of novel therapeutic agents, particularly for creating peptide mimetics and other bioactive molecules where stereochemical integrity is paramount.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) and metabolic disorder targets.
• Peptidomimetic Synthesis: Used to incorporate a constrained cyclohexyl-based amino acid analog into peptide chains, enhancing metabolic stability and bioavailability.
• Protecting Group Chemistry: The Fmoc (9-fluorenylmethoxycarbonyl) group provides a base-labile protecting strategy for the primary amine, essential for solid-phase peptide synthesis (SPPS) and other sequential coupling methodologies.
• Chemical Biology Probes: Serves as a precursor for labeling reagents and molecular probes used to study enzyme function and receptor-ligand interactions.
• Asymmetric Synthesis: Utilized in catalytic and stoichiometric asymmetric transformations due to its defined (1S,3R) stereochemistry, contributing to the synthesis of enantiomerically pure compounds.

Basic Information

Product Name	(9H-Fluoren-9-Yl)Methyl(((1S,3R)-3-(Aminomethyl)Cyclohexyl)Methyl)Carbamate Hydrochloride
CAS No.	1274891-91-6
Molecular Formula	C24H28N2O2 • HCl
Molecular Weight	412.95 g/mol (Free base: 376.49 g/mol)
Synonyms	Fmoc-(1S,3R)-3-(Aminomethyl)cyclohexylmethylamine Hydrochloride; ((9H-Fluoren-9-yl)methoxy)carbonyl-((1S,3R)-3-(aminomethyl)cyclohexyl)methylamine HCl; N-(((9H-Fluoren-9-yl)methoxy)carbonyl)-((1S,3R)-3-(aminomethyl)cyclohexyl)methanamine Hydrochloride; (1S,3R)-3-(Aminomethyl)-N-(((9H-fluoren-9-yl)methoxy)carbonyl)cyclohexanemethanamine Hydrochloride; Fmoc-Achc(3-CH2NH2)-OH derivative; (1S,3R)-Fmoc-3-(Aminomethyl)cyclohexylmethylamine HCl
EINECS	Contact for details

Quality Control

Our (9H-Fluoren-9-Yl)Methyl(((1S,3R)-3-(Aminomethyl)Cyclohexyl)Methyl)Carbamate Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and enantiomeric purity suitable for demanding research and development applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive); ensure containers are sealed under an inert atmosphere after opening to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.