Description

cis-3-Benzylaminocyclobutanecarboxylic Acid Tfa (1:1) is a high-purity, non-natural amino acid derivative featuring a cyclobutane ring core. This compound is a critical building block in pharmaceutical research and development, particularly for the synthesis of novel peptide-based therapeutics and constrained peptidomimetics. It is primarily utilized by medicinal chemists and process R&D teams in the pharmaceutical and biotechnology industries to create new chemical entities with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel active pharmaceutical ingredients (APIs), especially in metabolic disease and oncology research.
• Peptidomimetic Design: Used to introduce conformational rigidity into peptide backbones, improving receptor selectivity and in vivo stability.
• Chemical Biology Probe Synthesis: Serves as a scaffold for creating tool compounds to study enzyme function and protein-protein interactions.
• Process Chemistry: Employed in route scouting and optimization for the scalable production of candidate drugs.
• Academic Research: Utilized in universities and research institutes for fundamental studies in organic synthesis and medicinal chemistry.

Basic Information

Product Name	cis-3-Benzylaminocyclobutanecarboxylic Acid Tfa (1:1)
CAS No.	1274891-82-5
Molecular Formula	C13H16F3NO4
Molecular Weight	307.27 g/mol
Synonyms	cis-3-(Benzylamino)cyclobutanecarboxylic Acid Trifluoroacetate (1:1); (1s,3s)-3-(Benzylamino)cyclobutanecarboxylic Acid Trifluoroacetic Acid Salt; 3-(Benzylamino)cyclobutanecarboxylic Acid TFA Salt; cis-3-Benzylaminocyclobutanecarboxylic Acid TFA Salt; BACC TFA Salt; 3-BACC TFA; Cyclobutane-1-carboxylic acid, 3-(benzylamino)-, (1s,3s)-, compd. with 2,2,2-trifluoroacetic acid (1:1)
EINECS	Contact for details

Quality Control

Our cis-3-Benzylaminocyclobutanecarboxylic Acid Tfa (1:1) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting key parameters such as assay, chiral purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.