Description

1-Boc-7-(3-Ethoxy-3-Oxopropyl)-3,4-Dihydro-1,8-Naphthyridine is a high-purity, advanced pharmaceutical intermediate featuring a protected amine (Boc) and an ester functional group. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs) and novel drug candidates, particularly in the fields of oncology and neurology. It is primarily utilized by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of naphthyridine-based therapeutics.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the multi-step synthesis of potent drug molecules targeting various disease pathways.
• API Synthesis: Used in the research and commercial production of Active Pharmaceutical Ingredients (APIs), especially those with a 1,8-naphthyridine core structure.
• Medicinal Chemistry Research: Enables structure-activity relationship (SAR) studies and the exploration of new chemical entities in drug discovery programs.
• Preclinical Development: Supports the scale-up synthesis of candidate compounds for toxicology and pharmacokinetic studies.
• Custom Synthesis: A starting material for the tailored synthesis of specialized analogs and derivatives for proprietary research.

Basic Information

Product Name	1-Boc-7-(3-Ethoxy-3-Oxopropyl)-3,4-Dihydro-1,8-Naphthyridine
CAS No.	1272758-04-9
Molecular Formula	C19H26N2O4
Molecular Weight	346.42 g/mol
Synonyms	1-Boc-7-(3-ethoxy-3-oxopropyl)-3,4-dihydro-1,8-naphthyridine; tert-Butyl 7-(3-ethoxy-3-oxopropyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxylate; 1,8-Naphthyridine-1(2H)-carboxylic acid, 7-[3-(ethoxycarbonyl)propyl]-3,4-dihydro-, 1,1-dimethylethyl ester; 1-(tert-Butoxycarbonyl)-7-(3-ethoxy-3-oxopropyl)-1,2,3,4-tetrahydro-1,8-naphthyridine; Boc-Protected 1,8-Naphthyridine Ester Intermediate
EINECS	Contact for details

Quality Control

Our 1-Boc-7-(3-Ethoxy-3-Oxopropyl)-3,4-Dihydro-1,8-Naphthyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring material suitable for advanced research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound is sensitive to strong acids and organic solvents; keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.