Description

6-Nitrospiro[1,2,3,4-Tetrahydroquinazoline-2,1'-Cyclobutane]-4-One is a high-purity, advanced pharmaceutical intermediate characterized by its unique spirocyclic quinazolinone structure. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel drug candidates with potential therapeutic applications. It is primarily needed by R&D scientists and process chemists in the pharmaceutical and biotechnology industries for the development of new active pharmaceutical ingredients (APIs).

Application

• Key synthetic intermediate for the research and development of new pharmaceutical compounds.
• Building block in medicinal chemistry for constructing complex spirocyclic and fused heterocyclic scaffolds.
• Precursor in the synthesis of potential kinase inhibitors or other targeted therapeutic agents.
• Used in academic and industrial research for exploring structure-activity relationships (SAR).
• Critical material in process chemistry for scaling up novel synthetic routes.
• Reference standard for analytical method development and quality control in API manufacturing.

Basic Information

Product Name	6-Nitrospiro[1,2,3,4-Tetrahydroquinazoline-2,1'-Cyclobutane]-4-One
CAS No.	1272756-10-1
Molecular Formula	C12H11N3O3
Molecular Weight	245.24 g/mol
Synonyms	6-Nitrospiro[1,2,3,4-tetrahydroquinazoline-2,1'-cyclobutane]-4-one; 6-Nitrospiro(tetrahydroquinazoline-2,1'-cyclobutane)-4-one; 1272756-10-1; Spiro[cyclobutane-1,2'-[1,2,3,4]tetrahydroquinazolin]-4'-one, 6'-nitro-; 6'-Nitrospiro[cyclobutane-1,2'-[1,2,3,4]tetrahydroquinazolin]-4'-one
EINECS	Contact for details

Quality Control

Our 6-Nitrospiro[1,2,3,4-Tetrahydroquinazoline-2,1'-Cyclobutane]-4-One is manufactured under strict quality management systems. The product undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with batch-specific data are provided to guarantee traceability and compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.