Description

tert-Butyl 2,5-Dioxa-8-Aza-Spiro[3,5]Nonane-8-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic structure. This compound is valued for its role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting the central nervous system. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of complex drug molecules, especially for neurological and psychiatric applications.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a versatile linker component in the design of bifunctional degraders for targeted protein degradation.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to improve drug potency and selectivity.
• Process Chemistry & Scale-Up: Employed in the development and optimization of scalable synthetic routes for API manufacturing under GMP conditions.
• Chemical Biology Tool Development: Incorporated into molecular probes for studying enzyme function and cellular pathways.

Basic Information

Product Name	tert-Butyl 2,5-Dioxa-8-Aza-Spiro[3,5]Nonane-8-Carboxylate
CAS No.	1272412-68-6
Molecular Formula	C11H19NO4
Molecular Weight	229.27 g/mol
Synonyms	8-Boc-2,5-dioxa-8-azaspiro[3.5]nonane; tert-Butyl 2,5-dioxa-8-azaspiro[3.5]nonane-8-carboxylate; 2,5-Dioxa-8-azaspiro[3.5]nonane-8-carboxylic acid tert-butyl ester; 8-(tert-Butoxycarbonyl)-2,5-dioxa-8-azaspiro[3.5]nonane; Boc-2,5-dioxa-8-azaspiro[3.5]nonane; Spirocyclic Boc-protected amino acetal
EINECS	Contact for details

Quality Control

Our tert-Butyl 2,5-Dioxa-8-Aza-Spiro[3,5]Nonane-8-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.