Description

Cbz-L-Phe(3-Cl)-Oh is a protected amino acid derivative, specifically a chlorinated phenylalanine analog with a carboxybenzyl (Cbz) protecting group on the amine. This compound is a crucial chiral building block in the synthesis of complex peptides and peptidomimetics, offering precise control over molecular structure. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, including protease inhibitors and other bioactive molecules. Its defined stereochemistry and functional group protection make it an essential intermediate for advanced medicinal chemistry and life science research.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new drug candidates, particularly in peptide-based therapeutics.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate modified phenylalanine residues into peptide chains.
• Protease Inhibitor Development: A valuable precursor for creating inhibitors targeting specific enzymes due to the chlorinated aromatic side chain.
• Chemical Biology Research: Employed in the study of protein-protein interactions and the structure-activity relationships (SAR) of bioactive peptides.
• Custom Synthesis: Provides a starting point for the custom synthesis of non-natural amino acids and specialized fine chemicals for advanced research.

Basic Information

Product Name	Cbz-L-Phe(3-Cl)-Oh
CAS No.	1270296-41-7
Molecular Formula	C17H16ClNO4
Molecular Weight	333.77 g/mol
Synonyms	N-Carbobenzoxy-3-chloro-L-phenylalanine; Nα-Cbz-3-chloro-L-phenylalanine; Z-3-Chloro-L-phenylalanine; (2S)-2-[[(Benzyloxy)carbonyl]amino]-3-(3-chlorophenyl)propanoic acid; Nα-Z-3-Chloro-L-phenylalanine; Cbz-3-Cl-Phe-OH; Z-L-Phe(3-Cl)-OH; N-Cbz-3-chloro-L-phenylalanine
EINECS	Contact for details

Quality Control

Our Cbz-L-Phe(3-Cl)-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral analysis, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and specific impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.