Description

3-[4-(Trifluoromethoxy)Phenyl]Cyclobutane-1-Carboxylic Acid is a high-value, multifunctional chemical building block featuring a cyclobutane core substituted with a carboxylic acid and a trifluoromethoxy phenyl group. This compound matters for its unique structural properties, offering a rigid, strained ring system combined with the lipophilicity and metabolic stability imparted by the trifluoromethoxy moiety, which is highly sought after in advanced material and pharmaceutical research. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel small molecule drugs, particularly in oncology, CNS, and anti-inflammatory therapeutic areas.
• Agrochemical Research: Used in the synthesis of advanced herbicides, fungicides, and insecticides, leveraging the trifluoromethoxy group for enhanced bioactivity and environmental persistence.
• Material Science Precursor: Serves as a monomer or cross-linking agent for developing specialty polymers with tailored thermal and chemical resistance properties.
• Liquid Crystal & OLED Materials: The rigid, aromatic structure makes it a candidate for constructing core units in electronic display and lighting materials.
• Chemical Biology Probe: Utilized as a scaffold or labeling agent in probe development for studying biological targets and pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research institutions for bespoke synthesis projects and library production.

Basic Information

Product Name	3-[4-(Trifluoromethoxy)Phenyl]Cyclobutane-1-Carboxylic Acid
CAS No.	1269151-80-5
Molecular Formula	C12H11F3O3
Molecular Weight	260.21 g/mol
Synonyms	3-[4-(Trifluoromethoxy)phenyl]cyclobutane-1-carboxylic acid; 3-[4-(Trifluoromethoxy)phenyl]cyclobutanecarboxylic acid; 1-Cyclobutanecarboxylic acid, 3-[4-(trifluoromethoxy)phenyl]-; 3-(4-Trifluoromethoxyphenyl)cyclobutanecarboxylic acid; 3-(4-(Trifluoromethoxy)phenyl)cyclobutane-1-carboxylic acid; 1269151-80-5; 3-(4-Trifluoromethoxy-phenyl)-cyclobutanecarboxylic acid
EINECS	Contact for details

Quality Control

Our 3-[4-(Trifluoromethoxy)Phenyl]Cyclobutane-1-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its acidic nature, keep away from strong bases, oxidizing agents, and incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.