Description

3-(Trifluoromethyl)Oxetan-3-Amine Hydrochloride is a high-value, fluorinated oxetane building block with a protected amine functionality. This compound is critical for medicinal chemistry and agrochemical research, enabling the introduction of the metabolically stable trifluoromethyl group and the rigid oxetane scaffold into target molecules. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of small molecule drug candidates, particularly in oncology, CNS, and antiviral research.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity and environmental stability.
• Material Science Research: Serves as a monomer or cross-linker for developing specialty polymers with unique thermal and chemical resistance properties.
• Ligand and Catalyst Development: Employed in organometallic chemistry to create novel chiral ligands and catalysts for asymmetric synthesis.
• Peptide Mimetics: The oxetane ring acts as a bioisostere for carbonyl or other functional groups in the design of peptide analogs with improved pharmacokinetic profiles.
• Fluorine Chemistry Library Synthesis: An essential reagent for constructing diverse compound libraries for high-throughput screening in drug discovery.

Basic Information

Item	Detail
Product Name	3-(Trifluoromethyl)Oxetan-3-Amine Hydrochloride
CAS No.	1268883-21-1
Molecular Formula	C4H7ClF3NO
Molecular Weight	177.55 g/mol
Synonyms	3-Amino-3-(trifluoromethyl)oxetane hydrochloride; 3-(Trifluoromethyl)-3-oxetanamine hydrochloride; 3-Oxetanamine, 3-(trifluoromethyl)-, hydrochloride; 3-(Trifluoromethyl)azetidin-3-ol hydrochloride (tautomer); Trifluoromethyloxetan-3-amine HCl; TFMOA-HCl; 3-TFMOxetane-3-amine HCl
EINECS	Contact for details

Quality Control

Every batch of 3-(Trifluoromethyl)Oxetan-3-Amine Hydrochloride is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the rigorous standards required for advanced synthetic applications. A detailed Certificate of Analysis (COA) confirming identity, purity, and impurity profiles via HPLC, NMR, and MS is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.