Description

1-Ethynylcyclopropanamine Hydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a unique cyclopropane scaffold with an ethynylamine functional group. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in the development of central nervous system (CNS) and antiviral therapeutics. It is essential for research institutions and pharmaceutical manufacturers engaged in medicinal chemistry, process development, and the production of targeted small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key synthon for constructing complex molecules in the research and development of new drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its reactive ethynyl and amine groups.
• API Synthesis: Serves as a crucial precursor in the multi-step synthesis of target active pharmaceutical ingredients, especially those containing strained ring systems.
• CNS Drug Development: Employed in the creation of compounds targeting neurological pathways and receptors.
• Antiviral Agent Precursor: Utilized in the synthesis pathway for investigational antiviral medications.
• Chemical Biology Probes: Acts as a building block for creating molecular probes to study biological processes and enzyme functions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	1-Ethynylcyclopropanamine Hydrochloride
CAS No.	1268810-17-8
Molecular Formula	C5H8ClN
Molecular Weight	117.57 g/mol
Synonyms	1-Ethynylcyclopropanamine HCl; Cyclopropanamine, 1-ethynyl-, hydrochloride; 1-Ethynylcyclopropan-1-amine hydrochloride; 1-Amino-1-ethynylcyclopropane hydrochloride; 1-Ethynyl-1-aminocyclopropane hydrochloride; (1-Ethynylcyclopropyl)amine hydrochloride; 1268810-17-8; 1-Ethynylcyclopropylamine hydrochloride
EINECS	Contact for details

Quality Control

Our 1-Ethynylcyclopropanamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical R&D and cGMP (current Good Manufacturing Practice) applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if possible to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm
Single Unknown Impurity	≤ 0.5%
Total Impurities	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.