Description

Tigecycline (Open C-Ring D-Ring) Quinone is a key chemical intermediate and derivative of the broad-spectrum glycylcycline antibiotic, tigecycline. This compound is of significant value in pharmaceutical research and development, particularly for the synthesis of novel antibiotic analogs and for conducting structure-activity relationship (SAR) studies. It is primarily utilized by research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers focused on developing next-generation antimicrobial agents to combat drug-resistant bacterial infections.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of tigecycline analogs and novel glycylcycline antibiotics.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies to optimize antibiotic efficacy and reduce resistance.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in API manufacturing.
• Process Chemistry: Employed in route scouting and scale-up studies for the production of complex tetracycline-derived pharmaceuticals.
• Biochemical Research: Tool compound for investigating bacterial ribosome interaction and mechanisms of antibiotic action.

Basic Information

Product Name	Tigecycline (Open C-Ring D-Ring) Quinone
CAS No.	1268494-46-7
Molecular Formula	C₂₉H₃₉N₅O₈
Molecular Weight	585.65 g/mol
Synonyms	(4S,4aS,5aR,12aS)-9-(2-(tert-Butylamino)acetamido)-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide; Tigecycline Quinone Derivative; Open C-Ring D-Ring Tigecycline; Tigecycline Degradant/Intermediate; GAR-936 (Open Ring Quinone); (4S,4aS,5aR,12aS)-4,7-Bis(dimethylamino)-3,10,12,12a-tetrahydroxy-9-[2-(1,1-dimethylethylamino)acetamido]-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
EINECS	Contact for details

Quality Control

Our Tigecycline (Open C-Ring D-Ring) Quinone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent control of related substances. We provide Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment ensures material suitable for demanding pharmaceutical R&D and reference standard applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to minimize oxidation and degradation. The container should be kept in a cool, dry, and well-ventilated area, away from incompatible materials.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.