Description

[(3S)-3-Fluorooxolan-3-Yl]Methanol is a high-value, chiral fluorinated building block of significant interest in advanced organic synthesis. Its core value lies in the strategic incorporation of fluorine and a functionalized oxolane ring, enabling precise modulation of molecular properties such as metabolic stability, lipophilicity, and bioavailability. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries seeking to develop novel active ingredients with enhanced performance profiles.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of fluorinated active pharmaceutical ingredients (APIs), particularly in oncology, CNS, and antiviral drug discovery programs.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and insecticides where the fluorine atom improves biological activity and environmental persistence.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis, facilitating the creation of enantiomerically pure compounds.
• Material Science: Employed in the research of specialty polymers and liquid crystals, where the fluorinated moiety can alter surface energy and optical properties.
• Fluorine Chemistry Research: A valuable substrate for studying novel fluorination reactions and the stereochemical outcomes of transformations involving fluorinated heterocycles.

Basic Information

Product Name	[(3S)-3-Fluorooxolan-3-Yl]Methanol
CAS No.	1268492-92-7
Molecular Formula	C5H9FO2
Molecular Weight	120.12 g/mol
Synonyms	(3S)-3-Fluorotetrahydrofuran-3-methanol; (S)-3-(Hydroxymethyl)-3-fluorotetrahydrofuran; 3-Fluoro-3-(hydroxymethyl)oxolane (S)-; (3S)-3-Fluorooxolane-3-methanol; (S)-3-Fluorotetrahydrofuran-3-ylmethanol; (3S)-3-Fluorooxolan-3-ylmethanol; (S)-3-Fluoro-3-(hydroxymethyl)tetrahydrofuran
EINECS	Contact for details

Quality Control

Our [(3S)-3-Fluorooxolan-3-Yl]Methanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical and enantiomeric purity, meeting the exacting standards required for research and process development. A comprehensive Certificate of Analysis (COA) detailing identity, purity (by HPLC/GC), chiral purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its highly volatile nature, ensure containers are securely sealed when not in use. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.