Description

7'-Methyl-2',3'-Dihydro-1'H-Spiro[Cyclopentane-1,4'-Isoquinoline] is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic structure. This compound is of significant value for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology research. It is primarily sought by pharmaceutical R&D departments, contract research organizations (CROs), and fine chemical manufacturers engaged in innovative drug discovery and process development.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of complex drug candidates targeting neurological disorders.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• API Synthesis: Serves as a core structural unit in the development of new Active Pharmaceutical Ingredients, especially those with spirocyclic or tetrahydroisoquinoline motifs.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis and scale-up projects under cGMP conditions.
• Academic Research: Utilized in university and institutional labs for studying novel organic reactions and heterocyclic chemistry.
• Pre-clinical Development: Employed in the production of compounds for pharmacological profiling and toxicology studies.

Basic Information

Item	Details
Product Name	7'-Methyl-2',3'-Dihydro-1'H-Spiro[Cyclopentane-1,4'-Isoquinoline]
CAS No.	1268142-57-9
Molecular Formula	C14H19N
Molecular Weight	201.31 g/mol
Synonyms	7'-Methyl-2',3'-dihydro-1'H-spiro[cyclopentane-1,4'-isoquinoline]; 1'H-Spiro[cyclopentane-1,4'-isoquinoline], 2',3'-dihydro-7'-methyl-; Spiro[cyclopentane-1,4'-isoquinoline], 2',3'-dihydro-7'-methyl-1'H-; 7'-Methyl-1'H-spiro[cyclopentane-1,4'-isoquinoline]-2',3'-dihydro; 1268142-57-9
EINECS	Contact for details

Quality Control

Our 7'-Methyl-2',3'-Dihydro-1'H-Spiro[Cyclopentane-1,4'-Isoquinoline] is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing purity, impurities, and full analytical data are provided with every shipment. We support development and commercial projects with specifications tailored to meet cGMP and ICH Q7 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep the container sealed to protect from moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.