Description

3-(4-Aminobenzylamino)Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester Hydrochloride is a high-purity, protected pyrrolidine derivative used as a critical building block in advanced organic synthesis. This compound is essential for researchers and manufacturers requiring a versatile chiral amine intermediate with orthogonal protecting groups. It is primarily utilized in the pharmaceutical and agrochemical industries for the development of novel active ingredients, including protease inhibitors and other biologically active molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in protease inhibitor research.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides requiring specific chiral amine scaffolds.
• Peptidomimetics Research: Serves as a constrained scaffold for designing peptide mimics with enhanced metabolic stability.
• Chemical Biology Probes: Utilized in the creation of tool compounds for studying enzyme function and biological pathways.
• Asymmetric Catalysis Ligand Precursor: Acts as a starting material for synthesizing chiral ligands used in enantioselective transformations.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of complex molecules under cGMP conditions where applicable.

Basic Information

Product Name	3-(4-Aminobenzylamino)Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester Hydrochloride
CAS No.	1266226-12-3
Molecular Formula	C16H26N3O2 • HCl
Molecular Weight	329.86 g/mol (Free base: 292.40 g/mol)
Synonyms	1-Boc-3-[(4-aminobenzyl)amino]pyrrolidine hydrochloride; tert-Butyl 3-[(4-aminobenzyl)amino]pyrrolidine-1-carboxylate hydrochloride; N-Boc-3-(4-aminobenzylamino)pyrrolidine HCl; 1-(tert-Butoxycarbonyl)-3-[(4-aminophenyl)methyl]amino]pyrrolidine hydrochloride; 3-[(4-Aminobenzyl)amino]-1-(tert-butoxycarbonyl)pyrrolidine hydrochloride; Boc-3-(4-Aminobenzylamino)pyrrolidine HCl Salt; (S/R)-1-Boc-3-((4-aminobenzyl)amino)pyrrolidine hydrochloride
EINECS	Contact for details

Quality Control

Our 3-(4-Aminobenzylamino)Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical R&D and production. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.