Description

(S)-n-(4-Chlorobenzyl)Pyrrolidin-3-Amine Hydrochloride is a high-purity chiral amine building block and pharmaceutical intermediate. This compound is valued for its role in the synthesis of active pharmaceutical ingredients (APIs) and other biologically active molecules, particularly where stereochemical purity is critical. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical sectors for process development and scale-up.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and cardiovascular therapeutic areas.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in the production route of complex APIs requiring a specific (S)-enantiomer configuration.
• Agrochemical Research: Serves as a precursor in the development of new pesticides and herbicides with chiral centers.
• Chemical Biology & Medicinal Chemistry: Employed in research for structure-activity relationship (SAR) studies and hit-to-lead optimization.
• Catalyst & Ligand Development: Potential use in the synthesis of chiral ligands for asymmetric catalysis.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	(S)-n-(4-Chlorobenzyl)Pyrrolidin-3-Amine Hydrochloride
CAS No.	1264035-29-1
Molecular Formula	C11H16ClN2•HCl
Molecular Weight	261.62 g/mol (as hydrochloride salt)
Synonyms	(S)-1-[(4-Chlorophenyl)methyl]-3-pyrrolidinamine hydrochloride; (S)-N-(4-Chlorobenzyl)-3-aminopyrrolidine hydrochloride; (S)-3-Amino-1-(4-chlorobenzyl)pyrrolidine hydrochloride; (S)-1-(4-Chlorobenzyl)pyrrolidin-3-amine HCl; (S)-N-(p-Chlorobenzyl)-3-pyrrolidinamine hydrochloride; (S)-3-Amino-1-(4-chlorobenzyl)azetidine hydrochloride (related structure); Pyrrolidine, 3-amino-1-[(4-chlorophenyl)methyl]-, hydrochloride, (3S)-
EINECS	Contact for details

Quality Control

Our (S)-n-(4-Chlorobenzyl)Pyrrolidin-3-Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D and production. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.