Description

T-Boc-n-Amido-Peg6-Tos CAS NO 1264015-76-0 is a specialized heterobifunctional polyethylene glycol (PEG) derivative, engineered as a high-purity linker for advanced bioconjugation and pharmaceutical development. This compound is critical for creating stable, cleavable connections between biomolecules and other functional entities, such as drugs, dyes, or solid supports. It is an essential reagent for researchers and manufacturers in the fields of proteomics, antibody-drug conjugate (ADC) development, and peptide synthesis, where precise and reliable conjugation chemistry is paramount.

Application

• Antibody-Drug Conjugate (ADC) Linker: Serves as a key component in the construction of cleavable, stable linkers for attaching cytotoxic payloads to monoclonal antibodies.
• Peptide & Protein Modification: Used to introduce functional handles (e.g., amine-reactive groups) or to improve solubility and pharmacokinetic properties of peptides and proteins.
• Solid-Phase Synthesis Spacer: Acts as a hydrophilic, flexible spacer arm on solid supports for combinatorial chemistry and oligonucleotide synthesis.
• Biomolecule Immobilization: Facilitates the site-specific attachment of proteins, antibodies, or other biomolecules to surfaces for biosensor and diagnostic assay development.
• Cross-linking Reagent: Enables the controlled cross-linking of molecules in solution-phase chemistry for studying molecular interactions.
• Polymer Therapeutics: A building block for synthesizing sophisticated, multi-functional polymeric carriers for targeted drug delivery systems.

Basic Information

Product Name	T-Boc-n-Amido-Peg6-Tos
CAS No.	1264015-76-0
Molecular Formula	C31H53NO13S
Molecular Weight	655.8 g/mol
Synonyms	1-tert-Butyl 24-(4-methylphenyl)sulfonyl 2,5,8,11,14,17,20-heptaoxatetracosanedioate; tert-Butyl (1-((2-(2-(2-(2-(2-(2-(4-methylphenyl)sulfonyloxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethyl)carbamate; Boc-NH-PEG6-OTs; Boc-Amine-PEG6-Tosylate; N-Boc-1,8-diamino-3,6-dioxaoctane PEG6 Tosylate; T-Boc-N-amido-PEG6-tosylate; Heterobifunctional PEG derivative, Boc-PEG6-OTs; PEG Spacer, Boc-protected amine, tosylate-terminated
EINECS	Contact for details

Quality Control

Our T-Boc-n-Amido-Peg6-Tos is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, essential for sensitive bioconjugation applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as purity (by HPLC), identity confirmation (by NMR and MS), and moisture content. We adhere to cGMP principles where applicable, supporting its use in research and pre-clinical pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid or viscous liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.