Description

Protac Linker 31 is a specialized bifunctional linker compound, identified by CAS number 1263819-48-2, essential for constructing Proteolysis Targeting Chimeras (PROTACs). Its core value lies in enabling the precise assembly of heterobifunctional molecules that recruit E3 ubiquitin ligases to target proteins for degradation. This product is critically needed by researchers and developers in the pharmaceutical and biotechnology sectors focused on targeted protein degradation (TPD) therapeutics. It serves as a fundamental building block for creating novel drug candidates against challenging disease targets.

Application

• PROTAC Molecule Synthesis: A key structural component for linking E3 ubiquitin ligase ligands to target protein ligands.
• Drug Discovery Research: Used in medicinal chemistry for the development of novel targeted protein degraders.
• Chemical Biology Probes: Enables the creation of tools to study protein function and validate new therapeutic targets via the ubiquitin-proteasome system.
• Preclinical Development: Supports the optimization of linker length and composition to improve PROTAC efficacy and pharmacokinetic properties.
• Academic Research: Facilitates fundamental studies in cellular protein homeostasis and degradation pathways.
• Bioconjugation: Can be utilized in other bioconjugation strategies requiring specific spacer and linker functionalities.

Basic Information

Product Name	Protac Linker 31
CAS No.	1263819-48-2
Molecular Formula	C14H24N2O4
Molecular Weight	284.35 g/mol
Synonyms	1-((2-(2-(2-(2-Azidoethoxy)ethoxy)ethoxy)ethyl)amino)-3-((2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethyl)amino)propan-2-ol; PEG4-Azide-PEG2-VC-PAB; Azide-PEG4-VC-PAB; VC-PAB-PEG4-Azide; PROTAC Spacer 31; Heterobifunctional PEG Linker; E3 Ligase Linker; TPD Linker
EINECS	Contact for details

Quality Control

Our Protac Linker 31 is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency, suitable for research and development applications. Each batch undergoes comprehensive analytical characterization, including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and other critical parameters is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This compound is hygroscopic (moisture-sensitive); ensure the container is sealed under inert atmosphere or with desiccant after each use to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.