Description

2-Bromo-4-Fluoro-5-Iodo-Benzoic Acid is a highly functionalized benzoic acid derivative, serving as a critical multi-halogenated building block in advanced organic synthesis. Its unique substitution pattern makes it a valuable precursor for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and specialty agrochemicals. This compound is essential for research and production chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise, high-purity intermediates for complex coupling reactions and structure-activity relationship (SAR) studies.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially in medicinal chemistry for creating libraries of halogenated aromatic compounds.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and pesticides where the halogen atoms contribute to biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands used in transition metal catalysis and cross-coupling reactions.
• Material Science Research: Employed in the creation of organic electronic materials, liquid crystals, and polymers where halogen atoms tune electronic properties.
• Chemical Biology Probes: Useful for synthesizing tagged molecules and probes for studying biological systems and mechanisms.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences industry.

Basic Information

Product Name	2-Bromo-4-Fluoro-5-Iodo-Benzoic Acid
CAS No.	1263378-34-2
Molecular Formula	C7H3BrFIO2
Molecular Weight	344.90 g/mol
Synonyms	5-Iodo-2-bromo-4-fluorobenzoic acid; Benzoic acid, 2-bromo-4-fluoro-5-iodo-; 2-Bromo-4-fluoro-5-iodobenzoic acid; 4-Fluoro-2-bromo-5-iodobenzoic acid; 1263378-34-2; 5-Iodo-4-fluoro-2-bromobenzoic acid
EINECS	Contact for details

Quality Control

Our 2-Bromo-4-Fluoro-5-Iodo-Benzoic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including HPLC, NMR, and mass spectrometry to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support compliance with cGMP, ICH Q7, and other relevant regulatory guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and desiccated after opening to prevent degradation. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.