Description

4-Chloro-6-Fluoro-2-Trifluoromethyl-Quinoline-3-Carbonitrile is a high-value, multi-functionalized quinoline derivative that serves as a critical synthetic intermediate in advanced organic chemistry. Its unique molecular scaffold, featuring chloro, fluoro, and trifluoromethyl substituents, makes it an essential building block for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of potential drug candidates, particularly in kinase inhibitor and antiviral research programs.
• Agrochemical Synthesis: Building block for developing new-generation herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Material Science Research: Used in the development of organic electronic materials, such as OLED (Organic Light-Emitting Diode) emitters and charge-transport layers.
• Ligand and Catalyst Development: Serves as a core structure for creating novel chelating ligands and organocatalysts in asymmetric synthesis.
• Fluorine Chemistry Studies: A valuable substrate for investigating the effects of multiple fluorine atoms on reactivity and molecular properties.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific projects requiring complex heterocyclic cores.

Basic Information

Product Name	4-Chloro-6-Fluoro-2-Trifluoromethyl-Quinoline-3-Carbonitrile
CAS No.	1263286-10-7
Molecular Formula	C₁₂H₃ClF₄N₂
Molecular Weight	286.61 g/mol
Synonyms	4-Chloro-6-fluoro-2-(trifluoromethyl)quinoline-3-carbonitrile; 2-(Trifluoromethyl)-4-chloro-6-fluoroquinoline-3-carbonitrile; 4-Chloro-6-fluoro-2-trifluoromethyl-3-quinolinecarbonitrile; 3-Cyano-4-chloro-6-fluoro-2-trifluoromethylquinoline; Quinoline-3-carbonitrile, 4-chloro-6-fluoro-2-(trifluoromethyl)-; 1263286-10-7; 4-Chloro-6-fluoro-2-trifluoromethylquinoline-3-carbonitrile
EINECS	Contact for details

Quality Control

We maintain stringent quality control protocols for our fine chemical intermediates. Each batch of 4-Chloro-6-Fluoro-2-Trifluoromethyl-Quinoline-3-Carbonitrile is analyzed using advanced techniques like HPLC, GC-MS, and NMR to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. Our quality system is designed to support cGMP and ISO standards for reliable supply to regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize moisture exposure. Store away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.