Description

Spiro[8-Azabicyclo[3.2.1]Octane-3,3'-Pyrrolidine]-8-Carboxylic Acid, 5'-Oxo-, 1,1-Dimethylethyl Ester is a sophisticated spirocyclic organic building block of significant interest in advanced pharmaceutical research and development. This compound matters as a key chiral intermediate for constructing complex molecular architectures, particularly in the synthesis of active pharmaceutical ingredients (APIs) targeting the central nervous system. Pharmaceutical R&D chemists and process development scientists need this high-purity intermediate to enable efficient and scalable routes to novel therapeutic candidates.

Application

• Pharmaceutical Intermediate: A critical chiral building block in the synthesis of novel drug candidates, particularly for neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used in the exploration of structure-activity relationships (SAR) for new chemical entities targeting specific biological pathways.
• Process Chemistry & Scale-Up: Serves as a defined intermediate in the development of robust, scalable synthetic routes for Good Manufacturing Practice (GMP) production.
• Asymmetric Synthesis: Utilized in stereoselective reactions to construct complex molecules with high enantiomeric purity.
• Chemical Reference Standard: Employed as a high-purity analytical standard for method development and quality control in API manufacturing.
• Academic & Institutional Research: Used in universities and research institutes for studies in organic synthesis methodology and new reaction development.

Basic Information

Product Name	Spiro[8-Azabicyclo[3.2.1]Octane-3,3'-Pyrrolidine]-8-Carboxylic Acid, 5'-Oxo-, 1,1-Dimethylethyl Ester
CAS No.	1263279-47-5
Molecular Formula	C16H26N2O3
Molecular Weight	294.39 g/mol
Synonyms	tert-Butyl 5'-oxospiro[8-azabicyclo[3.2.1]octane-3,3'-pyrrolidine]-8-carboxylate; 8-[(1,1-Dimethylethoxy)carbonyl]-5'-oxospiro[8-azabicyclo[3.2.1]octane-3,3'-pyrrolidine]; Spiro[8-azabicyclo[3.2.1]octane-3,3'-pyrrolidine]-8-carboxylic acid, 5'-oxo-, 1,1-dimethylethyl ester; 1263279-47-5; tert-Butyl 5-oxo-2,8-diazaspiro[3.5]nonane-8-carboxylate (related structural name); Spirocyclic tropane-pyrrolidinone derivative
EINECS	Contact for details

Quality Control

Our Spiro[8-Azabicyclo[3.2.1]Octane-3,3'-Pyrrolidine]-8-Carboxylic Acid, 5'-Oxo-, 1,1-Dimethylethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity and identity confirmation, meeting the stringent requirements for pharmaceutical R&D applications. Comprehensive Certificates of Analysis (COA) detailing purity (by HPLC), chiral purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, it is recommended to store the material under an inert atmosphere or in a desiccator for long-term storage. Typical storage temperature is 2-8°C for extended stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.