Description

tert-Butyl 1,1-Difluoro-6-Azaspiro[2.5]Octane-6-Carboxylate is a high-value, multifunctional building block featuring a unique spirocyclic and difluorinated structure. This compound is essential for medicinal chemistry research and development, offering a versatile scaffold for creating novel bioactive molecules with enhanced metabolic stability and membrane permeability. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers for the synthesis of potential drug candidates, particularly in areas targeting the central nervous system and oncology.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) and oncology targets.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to introduce conformational constraint and fluorine atoms, improving drug-like properties.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a component for constructing linkers or warheads in bifunctional degrader molecules.
• Agrochemical Synthesis: Intermediate for developing advanced crop protection agents with improved efficacy and environmental profile.
• Material Science: Potential monomer or additive for creating specialty polymers with unique physical properties.
• Fluorine Chemistry Library: A valuable reagent for constructing diverse fluorinated compound libraries for high-throughput screening.

Basic Information

Product Name	tert-Butyl 1,1-Difluoro-6-Azaspiro[2.5]Octane-6-Carboxylate
CAS No.	1263263-29-1
Molecular Formula	C12H19F2NO2
Molecular Weight	247.28 g/mol
Synonyms	6-Boc-1,1-difluoro-6-azaspiro[2.5]octane; 1,1-Difluoro-6-azaspiro[2.5]octane-6-carboxylic acid tert-butyl ester; tert-Butyl 1,1-difluoro-6-azaspiro[2.5]octane-6-carboxylate; 6-(tert-Butoxycarbonyl)-1,1-difluoro-6-azaspiro[2.5]octane; Boc-1,1-difluoro-6-azaspiro[2.5]octane; 1,1-Difluoro-6-azaspiro[2.5]octane, 6-Boc protected
EINECS	Contact for details

Quality Control

Our tert-Butyl 1,1-Difluoro-6-Azaspiro[2.5]Octane-6-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ISO standards for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when prolonged exposure is anticipated to maintain purity and stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.