Description

4-Bromo-5,6,7,8-Tetrahydro-[1,5]Naphthyridine-2-Carbonitrile is a high-purity, advanced pharmaceutical intermediate featuring a brominated tetrahydro-naphthyridine core. This compound is of significant value for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel drug candidates. It is primarily sought after by R&D teams in the pharmaceutical and biotechnology sectors for creating targeted small-molecule therapies.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) targeting various disease pathways.
• Medicinal Chemistry Research: Used in hit-to-lead optimization and structure-activity relationship (SAR) studies for drug discovery programs.
• Kinase Inhibitor Development: The naphthyridine scaffold is common in the design of kinase inhibitors for oncology and inflammatory diseases.
• Chemical Library Synthesis: Employed in the construction of diverse compound libraries for high-throughput screening (HTS).
• Process Chemistry & Scale-Up: Serves as a critical intermediate during the route development and cGMP manufacturing of clinical trial materials.
• Agrochemical Research: Potential use in the development of new agrochemicals due to its heterocyclic structure.

Basic Information

Product Name	4-Bromo-5,6,7,8-Tetrahydro-[1,5]Naphthyridine-2-Carbonitrile
CAS No.	1263211-32-0
Molecular Formula	C9H8BrN3
Molecular Weight	238.09 g/mol
Synonyms	4-Bromo-5,6,7,8-tetrahydro[1,5]naphthyridine-2-carbonitrile; 4-Bromo-5,6,7,8-tetrahydro-1,5-naphthyridine-2-carbonitrile; 2-Cyano-4-bromo-5,6,7,8-tetrahydro-1,5-naphthyridine; 4-Bromo-2-cyano-5,6,7,8-tetrahydro-1,5-naphthyridine; 1263211-32-0; 4-Bromo-5,6,7,8-tetrahydro-[1,5]naphthyridine-2-carbonitrile; Tetrahydro-naphthyridine carbonitrile derivative
EINECS	Contact for details

Quality Control

Our 4-Bromo-5,6,7,8-Tetrahydro-[1,5]Naphthyridine-2-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and MS, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.