Description

7-Azaspiro[3.5]Nonane, 2,2-Difluoro- is a high-value, fluorinated spirocyclic amine building block of significant interest in modern synthetic chemistry. Its unique rigid, three-dimensional structure and the presence of fluorine atoms make it a critical intermediate for designing novel bioactive molecules with enhanced metabolic stability and binding affinity. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and advanced material science.

Application

• Pharmaceutical Intermediate: A key scaffold for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research, where its spirocyclic and fluorinated properties can improve pharmacokinetic profiles.
• Agrochemical Research: Used in the development of new-generation pesticides and herbicides, where the fluorine atoms can enhance biological activity and environmental stability.
• Ligand & Catalyst Development: Serves as a precursor for creating sophisticated ligands in asymmetric catalysis and organometallic chemistry.
• Material Science Precursor: Employed in the synthesis of specialty polymers and advanced organic materials that require specific structural motifs for performance tuning.
• Chemical Biology Probes: Utilized as a core structure for developing molecular probes and tools to study biological systems and enzyme functions.

Basic Information

Product Name	7-Azaspiro[3.5]Nonane, 2,2-Difluoro-
CAS No.	1263181-92-5
Molecular Formula	C8H13F2N
Molecular Weight	161.19 g/mol
Synonyms	2,2-Difluoro-7-azaspiro[3.5]nonane; 7-Azaspiro[3.5]nonane, 2,2-difluoro-; 2,2-Difluoro-7-azaspiro[3.5]nonane; Difluorinated 7-Azaspiro[3.5]nonane; 2,2-Difluoro-1-azaspiro[3.5]nonane (alternative numbering); 7-Aza-2,2-difluorospiro[3.5]nonane; F-spirocyclic amine intermediate; 2,2-Difluoro-7-azaspiro[3.5]nonane hydrochloride (salt form)
EINECS	Contact for details

Quality Control

Our 7-Azaspiro[3.5]Nonane, 2,2-Difluoro- is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, essential for sensitive R&D and scale-up processes. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality systems are designed to support cGMP compliance for pharmaceutical applications, and we welcome audits and custom specification development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.