Description

tert-Butyl 3,3-Difluoro-1,7-Diazaspiro[4.4]Nonane-1-Carboxylate is a high-value, multifunctional spirocyclic building block designed for advanced pharmaceutical and agrochemical research. Its unique difluorinated diazaspiro[4.4]nonane core offers significant potential for modulating the physicochemical properties, metabolic stability, and binding affinity of lead compounds. This intermediate is primarily sought after by medicinal chemists and process development scientists in the pharmaceutical industry for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the research and development of new drug candidates, particularly in central nervous system (CNS), oncology, and anti-infective therapeutic areas.
• Medicinal Chemistry Scaffold: Used to introduce conformational constraint and fluorine atoms into molecules, enhancing potency, selectivity, and metabolic stability (Lipinski's rule of five optimization).
• Agrochemical Synthesis: Serves as a precursor in the development of novel herbicides, fungicides, and insecticides, where the spirocyclic structure can improve environmental profile and efficacy.
• Chemical Biology Probe Development: Utilized in the synthesis of tool compounds for target validation and mechanistic studies in biological systems.
• Process Chemistry & Scale-up: Employed in route scouting and optimization for the commercial-scale production of active pharmaceutical ingredients (APIs).
• Library Synthesis for High-Throughput Screening (HTS): A valuable scaffold for generating diverse compound libraries to explore new chemical space in drug discovery campaigns.

Basic Information

Product Name	tert-Butyl 3,3-Difluoro-1,7-Diazaspiro[4.4]Nonane-1-Carboxylate
CAS No.	1263180-36-4
Molecular Formula	C12H20F2N2O2
Molecular Weight	262.30 g/mol
Synonyms	1-Boc-3,3-difluoro-1,7-diazaspiro[4.4]nonane; 3,3-Difluoro-1,7-diazaspiro[4.4]nonane-1-carboxylic acid tert-butyl ester; tert-Butyl 3,3-difluoro-1,7-diazaspiro[4.4]nonane-1-carboxylate; 1,7-Diazaspiro[4.4]nonane-1-carboxylic acid, 3,3-difluoro-, 1,1-dimethylethyl ester; Boc-3,3-difluoro-1,7-diazaspiro[4.4]nonane; 1263180-36-4; 3,3-Difluoro-1-Boc-1,7-diazaspiro[4.4]nonane
EINECS	Contact for details

Quality Control

Our tert-Butyl 3,3-Difluoro-1,7-Diazaspiro[4.4]Nonane-1-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high purity and consistent identity. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We support development and commercial projects requiring compliance with cGMP and ICH Q7 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.