Description

tert-Butyl 4,4-Difluoro-2,8-Diazaspiro[4.5]Decane-2-Carboxylate is a high-value, fluorinated spirocyclic building block designed for advanced pharmaceutical and agrochemical research. This compound is critical for medicinal chemists seeking to modulate the physicochemical and metabolic properties of drug candidates through the introduction of a rigid, fluorine-containing scaffold. It is primarily utilized by R&D teams in the pharmaceutical, biotechnology, and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of small molecule therapeutics targeting central nervous system (CNS) disorders, oncology, and metabolic diseases.
• Medicinal Chemistry: Used to introduce conformational rigidity and fluorine atoms into lead compounds to improve potency, metabolic stability, and membrane permeability.
• Agrochemical Research: Serves as a sophisticated intermediate in the development of new-generation herbicides, fungicides, and insecticides with enhanced efficacy.
• Chemical Biology Probe Development: Employed in the creation of tool compounds and probes for studying enzyme function and biological pathways.
• Process Chemistry & Scale-up: Suitable for use in route scouting and optimization for the commercial-scale production of active pharmaceutical ingredients (APIs).
• Library Synthesis: A valuable scaffold for generating diverse compound libraries for high-throughput screening (HTS) in drug discovery campaigns.

Basic Information

Product Name	tert-Butyl 4,4-Difluoro-2,8-Diazaspiro[4.5]Decane-2-Carboxylate
CAS No.	1263180-19-3
Molecular Formula	C13H22F2N2O2
Molecular Weight	276.33 g/mol
Synonyms	2,8-Diazaspiro[4.5]decane-2-carboxylic acid, 4,4-difluoro-, 1,1-dimethylethyl ester; 4,4-Difluoro-2,8-diazaspiro[4.5]decane-2-carboxylic acid tert-butyl ester; tert-Butyl 4,4-difluoro-2,8-diazaspiro[4.5]decane-2-carboxylate; 1263180-19-3; BOC-4,4-Difluoro-2,8-diazaspiro[4.5]decane; 4,4-Difluoro-2-Boc-2,8-diazaspiro[4.5]decane
EINECS	Contact for details

Quality Control

Our production of tert-Butyl 4,4-Difluoro-2,8-Diazaspiro[4.5]Decane-2-Carboxylate adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity for critical R&D applications. All materials are characterized by advanced analytical techniques including NMR, HPLC, and MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.