Description

(R)-Cyclopropyl(4-(Trifluoromethyl)Phenyl)Methanamine Hydrochloride is a high-purity chiral amine building block essential for modern pharmaceutical research and development. This compound serves as a critical intermediate in the synthesis of active pharmaceutical ingredients (APIs), particularly for targeted therapies. It is primarily needed by pharmaceutical companies, contract research organizations (CROs), and advanced chemical synthesis laboratories engaged in drug discovery programs for central nervous system (CNS) disorders, oncology, and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, especially those targeting specific receptors.
• Active Pharmaceutical Ingredient (API) Development: Used in the research and process development of new APIs requiring a cyclopropylamine pharmacophore.
• Asymmetric Synthesis: Employed as a chiral auxiliary or resolving agent in stereoselective chemical reactions.
• Medicinal Chemistry Research: A valuable building block for constructing compound libraries for high-throughput screening (HTS) and structure-activity relationship (SAR) studies.
• Process Chemistry & Scale-Up: Serves as a starting material for optimizing scalable synthetic routes under GMP or non-GMP conditions.
• Reference Standard: Used as an analytical standard for quality control and method validation in pharmaceutical analysis.

Basic Information

Product Name	(R)-Cyclopropyl(4-(Trifluoromethyl)Phenyl)Methanamine Hydrochloride
CAS No.	1263094-36-5
Molecular Formula	C11H13F3N·HCl
Molecular Weight	249.68 g/mol (Free base: 214.22 g/mol)
Synonyms	(1R)-1-Cyclopropyl-1-[4-(trifluoromethyl)phenyl]methanamine hydrochloride; (R)-1-(4-(Trifluoromethyl)phenyl)cyclopropanamine hydrochloride; (R)-α-Cyclopropyl-4-(trifluoromethyl)benzylamine hydrochloride; (R)-CPTMA HCl; (R)-1-Cyclopropyl-1-(4-trifluoromethylphenyl)methylamine hydrochloride; (R)-1-[4-(Trifluoromethyl)phenyl]cyclopropanamine hydrochloride; Benzenemethanamine, α-cyclophenyl-4-(trifluoromethyl)-, (αR)-, hydrochloride
EINECS	Contact for details

Quality Control

Our (R)-Cyclopropyl(4-(Trifluoromethyl)Phenyl)Methanamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, GC) are provided for every shipment, ensuring traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.