Description

3,4,5-Trifluorobenzohydrazide is a high-purity fluorinated aromatic hydrazide derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its trifluoromethyl-substituted benzohydrazide structure, which imparts unique electronic and steric properties essential for developing novel compounds with enhanced bioactivity and stability. This intermediate is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating new active ingredients, particularly in medicinal chemistry programs targeting CNS and metabolic diseases.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel drug candidates, especially in protease inhibitor and kinase inhibitor research.
• Agrochemical Synthesis: Building block for next-generation herbicides and fungicides, leveraging the fluorine atoms for improved lipophilicity and membrane penetration.
• Ligand & Catalyst Precursor: Used in the preparation of specialized ligands for transition metal catalysis in cross-coupling reactions.
• Material Science Research: Intermediate for synthesizing fluorinated polymers and liquid crystals with specific optical and electronic properties.
• Chemical Biology Probes: Utilized in the design of activity-based probes and fluorogenic substrates for enzyme studies.

Basic Information

Product Name	3,4,5-Trifluorobenzohydrazide
CAS No.	1263064-36-3
Molecular Formula	C7H5F3N2O
Molecular Weight	190.12 g/mol
Synonyms	3,4,5-Trifluorobenzoic acid hydrazide; Benzoic acid, 3,4,5-trifluoro-, hydrazide; 3,4,5-Trifluorobenzoylhydrazine; 1263064-36-3; 3,4,5-Trifluorobenzohydrazine; Trifluorobenzohydrazide; TFBAH
EINECS	Contact for details

Quality Control

Our 3,4,5-Trifluorobenzohydrazide is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and scale-up applications. Certificates of Analysis (COA) documenting all critical quality attributes are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.