Description

N2,N3-Bis-(tert-Butyloxycarbonyl)-N1-(9-Fluorenylmethyloxycarbonyl)-1,5,10,14-Tetra-Aza-Quatrodecan-N4-Succinamic Acid CAS NO 1263046-90-7 is a sophisticated, multi-protected tetra-aza macrocyclic derivative designed for advanced peptide and chemical synthesis. This compound is a critical building block for researchers and manufacturers developing complex molecular architectures, particularly in pharmaceutical discovery and bioconjugation. It is essential for chemists in the life sciences sector requiring high-purity, specialized intermediates for constructing peptide-based therapeutics, diagnostic agents, and novel materials.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a key intermediate for the controlled incorporation of a tetra-aza macrocyclic structure into peptide chains, enabling the creation of novel peptide-drug conjugates.
• Pharmaceutical Research & Development: Used in the synthesis of complex active pharmaceutical ingredients (APIs) and prodrugs, particularly those requiring specific chelating or structural motifs.
• Bioconjugation and Linker Chemistry: Acts as a versatile scaffold for attaching fluorophores, drugs, or other payloads to biomolecules like antibodies or proteins.
• Macrocyclic Compound Synthesis: A fundamental precursor for constructing custom-designed macrocycles with potential applications in catalysis, molecular recognition, and material science.
• Chemical Biology Probes: Utilized to develop specialized probes for studying biological processes, enzyme mechanisms, and cellular pathways.
• High-Purity Reference Standard: Supplied as a certified reference material for analytical method development and quality control in GMP environments.

Basic Information

Product Name	N2,N3-Bis-(tert-Butyloxycarbonyl)-N1-(9-Fluorenylmethyloxycarbonyl)-1,5,10,14-Tetra-Aza-Quatrodecan-N4-Succinamic Acid
CAS No.	1263046-90-7
Molecular Formula	C46H66N6O10
Molecular Weight	863.06 g/mol
Synonyms	Fmoc-Lys(Boc)-Dap(Boc)-Dap-Succ-OH; Fmoc-Lys(Boc)-Dap(Boc)-Dap-Succinic Acid; 1,5,10,14-Tetraazacycloheptadecane-1,5,10,14-tetraacetic acid derivative; Boc2-Lys(Fmoc)-Dap(Boc)-Dap-Succ; Nα-Fmoc-Nε-Boc-L-Lysyl-Nα-Boc-L-2,3-diaminopropionyl-L-2,3-diaminopropionyl-succinamic acid; Fmoc-Lys(Boc)-Dap(Boc)-Dap-β-Ala-OH (common structural alias); Protected Tetra-aza Macrocyclic Building Block
EINECS	Contact for details

Quality Control

Our N2,N3-Bis-(tert-Butyloxycarbonyl)-N1-(9-Fluorenylmethyloxycarbonyl)-1,5,10,14-Tetra-Aza-Quatrodecan-N4-Succinamic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, MS for identity confirmation, and NMR for structural verification, to ensure it meets the high standards required for research and pharmaceutical applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis. For long-term storage, keep under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC-MS)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.